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Single-cell RNA-sequencing in asthma research.
Tang, Weifeng; Li, Mihui; Teng, Fangzhou; Cui, Jie; Dong, Jingcheng; Wang, Wenqian.
  • Tang W; Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Li M; The Institutes of Integrative Medicine, Fudan University, Shanghai, China.
  • Teng F; Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Cui J; The Institutes of Integrative Medicine, Fudan University, Shanghai, China.
  • Dong J; Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Wang W; The Institutes of Integrative Medicine, Fudan University, Shanghai, China.
Front Immunol ; 13: 988573, 2022.
Article in English | MEDLINE | ID: covidwho-2198863
ABSTRACT
Asthma is a complex and heterogeneous disease with multicellular involvement, and knowledge gaps remain in our understanding of the pathogenesis of asthma. Efforts are still being made to investigate the immune pathogenesis of asthma in order to identify possible targets for prevention. Single cell RNA sequencing (scRNA-seq) technology is a useful tool for exploring heterogeneous diseases, identifying rare cell types and distinct cell subsets, enabling elucidation of key processes of cell differentiation, and understanding regulatory gene networks that predict immune function. In this article, we provide an overview of the importance of scRNA-seq for asthma research, followed by an in-depth discussion of the results in recent years, in order to provide new ideas for the pathogenesis, drug development and treatment of asthma.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Single-Cell Analysis Type of study: Prognostic study / Qualitative research Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.988573

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Single-Cell Analysis Type of study: Prognostic study / Qualitative research Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.988573