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Sleep quality was associated with adverse reactions after coronavirus disease 2019 vaccination among healthcare workers: A longitudinal paired study.
Xiao, Ning; Xu, Xingli; Ma, Zhiyue; Yu, Xiaoxu; Feng, Yong; Li, Bilan; Liu, Yuping; He, Gang; Fan, Jiangang; Li, Bin; Zhao, Xiaolong.
  • Xiao N; Department of Health Management Center and Institute of Health Management, Sichuan Provincial People's Hospital, Chengdu, China.
  • Xu X; Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Ma Z; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Yu X; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Feng Y; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Li B; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Liu Y; Department of Health Management Center and Institute of Health Management, Sichuan Provincial People's Hospital, Chengdu, China.
  • He G; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Fan J; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Li B; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Zhao X; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Front Behav Neurosci ; 16: 867650, 2022.
Article in English | MEDLINE | ID: covidwho-2237121
ABSTRACT

Background:

Many countries have currently relied on various types of vaccines for the public to control the coronavirus disease 2019 (COVID-19) pandemic. The adverse reactions (ARs) after vaccination may affect vaccination coverage and confidence. However, whether sleep quality was associated with ARs after vaccination remains unclear.

Methods:

We designed a longitudinal paired study within a hospital setting. We collected data about the side effects within 7 days after two doses of scheduled vaccination among healthcare workers (HCWs). All HCWs were asked to complete a sleep survey indexed by the Pittsburgh Sleep Quality Index (PSQI) before vaccination and after a 1-month follow-up. Then, we explored the relationship between sleep quality before or after vaccination and the occurrence of ARs.

Results:

A total of 345 HCWs were recruited to receive COVID-19 vaccination. The sleep quality became worse after vaccination. All local and systemic reactions were mild or moderate in severity (32.46%), and no serious adverse event was reported. Binary logistic regression showed participants with poor sleep quality (PSQI > 5) than good sleep quality (PSQI ≤ 5) before the two doses of vaccination, respectively, exhibited 1.515 and 1.107 times risk of ARs after each vaccination (both p < 0.001).

Conclusion:

There is an apparently complex bidirectional relationship between sleep quality and COVID-19 vaccination adverse effects. Poor sleep quality significantly increases the risk of mild ARs after vaccination, while vaccination may cause a temporary decline in sleep quality.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Front Behav Neurosci Year: 2022 Document Type: Article Affiliation country: Fnbeh.2022.867650

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Front Behav Neurosci Year: 2022 Document Type: Article Affiliation country: Fnbeh.2022.867650