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Genetic Predisposition to Neurological Complications in Patients with COVID-19.
Sahajpal, Nikhil Shri; Hastie, Alex R; Schieck, Maximilian; Mondal, Ashis K; Felde, Marc; van der Made, Caspar I; Chou, Janet S; Randolph, Adrienne G; Illig, Thomas; Zody, Michael C; Brownstein, Catherine A; Beggs, Alan H; Hoischen, Alexander; Chaubey, Alka; Kolhe, Ravindra.
  • Sahajpal NS; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
  • Hastie AR; Greenwood Genetic Center, Greenwood, SC 29646, USA.
  • Schieck M; Bionano Genomics, Inc., San Diego, CA 92121, USA.
  • Mondal AK; Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.
  • Felde M; RESIST-Cluster of Excellence 2155, Hannover Medical School, 30625 Hannover, Germany.
  • van der Made CI; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
  • Chou JS; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
  • Randolph AG; Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands.
  • Illig T; Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
  • Zody MC; Radboud Expertise Center for Immunodeficiency and Autoinflammation, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
  • Brownstein CA; Division of Immunology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Beggs AH; Department of Anesthesiology, Critical Care, and Pain Medicine, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Hoischen A; Departments of Anesthesia and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Chaubey A; Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.
  • Kolhe R; RESIST-Cluster of Excellence 2155, Hannover Medical School, 30625 Hannover, Germany.
Biomolecules ; 13(1)2023 01 09.
Article in English | MEDLINE | ID: covidwho-2199741
ABSTRACT
Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Biom13010133

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Biom13010133