Methods for the Assessment of NET Formation: From Neutrophil Biology to Translational Research.
Int J Mol Sci
; 23(24)2022 Dec 13.
Article
in English
| MEDLINE | ID: covidwho-2200320
ABSTRACT
Several studies have indicated that a neutrophil extracellular trap (NET) formation, apart from its role in host defense, can contribute to or drive pathogenesis in a wide range of inflammatory and thrombotic disorders. Therefore, NETs may serve as a therapeutic target or/and a diagnostic tool. Here, we compare the most commonly used techniques for the assessment of NET formation. Furthermore, we review recent data from the literature on the application of basic laboratory tools for detecting NET release and discuss the challenges and the advantages of these strategies in NET evaluation. Taken together, we provide some important insights into the qualitative and quantitative molecular analysis of NETs in translational medicine today.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Extracellular Traps
/
Neutrophils
Type of study:
Experimental Studies
/
Qualitative research
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijms232415823
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