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Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry.
De Luca, Giuseppe; Manzo-Silberman, Stephane; Algowhary, Magdy; Uguz, Berat; Oliveira, Dinaldo C; Ganyukov, Vladimir; Busljetik, Oliver; Cercek, Miha; Okkels, Lisette; Loh, Poay Huan; Calmac, Lucian; Ferrer, Gerard Roura I; Quadros, Alexandre; Milewski, Marek; Scotto di Uccio, Fortunato; von Birgelen, Clemens; Versaci, Francesco; Ten Berg, Jurrien; Casella, Gianni; Wong Sung Lung, Aaron; Kala, Petr; Díez Gil, José Luis; Carrillo, Xavier; Dirksen, Maurits; Becerra, Victor; Lee, Michael Kang-Yin; Juzar, Dafsah Arifa; de Moura Joaquim, Rodrigo; Paladino, Roberto; Milicic, Davor; Davlouros, Periklis; Bakraceski, Nikola; Zilio, Filippo; Donazzan, Luca; Kraaijeveld, Adriaan; Galasso, Gennaro; Arpad, Lux; Marinucci, Lucia; Guiducci, Vincenzo; Menichelli, Maurizio; Scoccia, Alessandra; Yamac, Aylin Hatice; Ugur Mert, Kadir; Flores Rios, Xacobe; Kovarnik, Tomas; Kidawa, Michal; Moreu, Josè; Flavien, Vincent; Fabris, Enrico; Martínez-Luengas, Iñigo Lozano.
  • De Luca G; Division of Cardiology, AOU "Policlinico G. Martino", Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
  • Manzo-Silberman S; Division of Cardiology, Nuovo Galeazzi-Sant'Ambrogio Hospital, 20161 Milan, Italy.
  • Algowhary M; ACTION Study Group, Institute of Cardiology-Hôpital Pitié-Salpêtrière (AP-HP), Sorbonne University, 75651 Paris, France.
  • Uguz B; Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut 71515, Egypt.
  • Oliveira DC; Division of Cardiology, Bursa City Hospital, 16000 Bursa, Turkey.
  • Ganyukov V; Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife 50670-901, Brazil.
  • Busljetik O; Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, 650000 Kemerovo, Russia.
  • Cercek M; University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, 1000 Skopje, North Macedonia.
  • Okkels L; Department of Cardiology, Medical Center Ljubljana, 1000 Ljubljana, Slovenia.
  • Loh PH; Division of Cardiology, Odense Universitets Hospital, 5000 Odense, Denmark.
  • Calmac L; Department of Cardiology, National University Hospital, Singapore 117597, Singapore.
  • Ferrer GRI; Clinic Emergency Hospital of Bucharest, 014461 Bucharest, Romania.
  • Quadros A; Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, 08016 Barcelona, Spain.
  • Milewski M; Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90040-371, Brazil.
  • Scotto di Uccio F; Division of Cardiology, Medical University of Silezia, 40-002 Katowice, Poland.
  • von Birgelen C; Division of Cardiology, Ospedale del Mare, 00156 Napoli, Italy.
  • Versaci F; Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, 7541 Enschede, The Netherlands.
  • Ten Berg J; Division of Cardiology, Ospedale Santa Maria Goretti Latina, 04100 Latina, Italy.
  • Casella G; Division of Cardiology, St. Antonius Hospital, 3434 Nieuwegein, The Netherlands.
  • Wong Sung Lung A; Division of Cardiology, Ospedale Maggiore Bologna, 40100 Bologna, Italy.
  • Kala P; Department of Cardiology, National Heart Center, Singapore 169609, Singapore.
  • Díez Gil JL; University Hospital Brno, Medical Faculty of Masaryk University, 60200 Brno, Czech Republic.
  • Carrillo X; Sección de la Unidad de Hemodinámica H. Universitario y Politécnico La Fe, 46001 Valencia, Spain.
  • Dirksen M; Hospital Germans Triasi Pujol, 8918 Badalona, Spain.
  • Becerra V; Division of Cardiology, Northwest Clinics, 1811 Alkmaar, The Netherlands.
  • Lee MK; Hospital Clínico Universitario Virgen de la Victoria, 29000 Malaga, Spain.
  • Juzar DA; Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong.
  • de Moura Joaquim R; Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center "Harapan Kita", Jakarta 11420, Indonesia.
  • Paladino R; Instituto de Cardiologia de Santa Catarina Praia Comprida, São José 88103-901, Brazil.
  • Milicic D; Division of Cardiology, Clinica Villa dei Fiori, 80011 Acerra, Italy.
  • Davlouros P; Department of Cardiology, University Hospital Centre, University of Zagreb, 10000 Zagreb, Croatia.
  • Bakraceski N; Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, 26221 Patras, Greece.
  • Zilio F; Center for Cardiovascular Diseases, 6000 Ohrid, North Macedonia.
  • Donazzan L; Division of Cardiology, Ospedale Santa Chiara di Trento, 38014 Trento, Italy.
  • Kraaijeveld A; Division of Cardiology, Ospedale "S. Maurizio" Bolzano, 39100 Bolzano, Italy.
  • Galasso G; Division of Cardiology, 3584 Utrecht, The Netherlands.
  • Arpad L; Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, 84070 Salerno, Italy.
  • Marinucci L; Maastricht University Medical Center, 6229 Maastricht, The Netherlands.
  • Guiducci V; Division of Cardiology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", 61121 Pesaro, Italy.
  • Menichelli M; Division of Cardiology, AUSL-IRCCS Reggio Emilia, 42121 Reggio Emilia, Italy.
  • Scoccia A; Division of Cardiology, Ospedale "F. Spaziani", 03100 Frosinone, Italy.
  • Yamac AH; Division of Cardiology, Ospedale "Sant'Anna", 44121 Ferrara, Italy.
  • Ugur Mert K; Department of Cardiology, Bezmialem Vakif University Hospital, 34093 Istanbul, Turkey.
  • Flores Rios X; Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 02640 Eskisehir, Turkey.
  • Kovarnik T; Complexo Hospetaliero Universitario La Coruna, 15001 La Coruna, Spain.
  • Kidawa M; University Hospital Prague, 12808 Prague, Czech Republic.
  • Moreu J; Central Hospital of Medical University of Lodz, 90-008 Lodz, Poland.
  • Flavien V; Division of Cardiology, Complejo Hospitalario de Toledo, 45001 Toledo, Spain.
  • Fabris E; Division of Cardiology, Center Hospitalier Universitaire de Lille, 59000 Lille, France.
  • Martínez-Luengas IL; Azienda Ospedaliero-Universitaria Ospedali Riuniti, 34142 Trieste, Italy.
J Clin Med ; 12(3)2023 Jan 23.
Article in English | MEDLINE | ID: covidwho-2200435
ABSTRACT

BACKGROUND:

Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry.

METHODS:

This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March-June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality.

RESULTS:

We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI 0.825-0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31-2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96-1.34], p = 0.12).

CONCLUSIONS:

The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number NCT 04412655.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2023 Document Type: Article Affiliation country: Jcm12030896

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2023 Document Type: Article Affiliation country: Jcm12030896