[Analysis of the whole genome traceability and transmission path simulation experiment of the local cluster COVID-19 epidemic].
Zhonghua Yu Fang Yi Xue Za Zhi
; 56(12): 1795-1802, 2022 Dec 06.
Article
in Chinese
| MEDLINE | ID: covidwho-2201072
ABSTRACT
Objective:
To trace and characterize the whole genome of SARS-CoV-2 of confirmed cases in the outbreak of COVID-19 on July 31, 2021 in Henan Province.Method:
Genome-wide sequencing and comparative analysis were performed on positive nucleic acid samples of SARS-CoV-2 from 167 local cases related to the epidemic on July 31, 2021, to analyze the consistency and evolution of the whole genome sequence of virus.Results:
Through high-throughput sequencing, a total of 106 cases of SARS-CoV-2 whole genome sequences were obtained. The results of genome analysis showed that the whole genome sequences of 106 cases belonged to the VOC/Delta variant strain (B.1.617.2 clade), and the whole genome sequences of 106 cases were shared with the genomes of 3 imported cases from Myanmar admitted to a hospital in Zhengzhou. On the basis of 45 nucleotide sites, 1-5 nucleotide variation sites were added, and the genome sequence was highly homologous.Conclusion:
Combined with the comprehensive analysis of viral genomics, transmission path simulation experiments and epidemiology, it is determined that the local new epidemic in Henan Province is caused by imported cases in the nosocomial area, and the spillover has caused localized infection in the community. At the same time, it spills over to some provincial cities and results in localized clustered epidemics.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Epidemics
/
COVID-19
Type of study:
Randomized controlled trials
Topics:
Variants
Limits:
Humans
Language:
Chinese
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2022
Document Type:
Article
Affiliation country:
Cma.j.cn112150-20220127-00095
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