A rare presentation of Multisystem Inflammatory Syndrome in Neonates (MIS-N) with a cerebral haemorrhage

ABSTRACT

Covid-19 infection during pregnancy poses diverse challenges to the developing fetus1. Multisystem Inflammatory Syndrome in Children (MIS-C) usually develops around 4-8 weeks after Covid-19 infection due to immune dysregulation2. Pathogenesis of MIS-N is similar to MIS-C but the Covid-19 infection occurs in the mother while the multiorgan inflammation occurs in the neonate due to the transfer of maternal antibodies3. Gastrointestinal bleeding and thrombotic events are known associations of MIS-N3;however, there are only a few cases with cerebral haemorrhage4. We describe a case of MIS-N with cerebral haemorrhage and microangiopathic haemolytic anaemia (MAHA) that showed a good response to immunotherapy with intravenous immunoglobulin (IVIG) © Open Access Article published under the Creative Commons Attribution CC-BY License