Role of Endotoxin Adsorption in Severe Gram Negative Sepsis after Covid 19 Infection in a Renal Transplant Recipient A Case Report

ABSTRACT

BACKGROUND: ROLE OF HEMOADSORBTION IN GRAM NEGATIVE SEPSIS AIM OF THE STUDY TO SEE THE EFFICACY OF NOVEL ALTECO LPS ADSORBER IN A PATIENT WITH SEVERE GRAM NEGATIVE SEPTIC SHOCK METHODS: ALTECO LPS ADSORBER WAS USED IN A POST RENAL TRANSPLANT RECIPIENT WITH SEVERE SEPTIC SHOCK WITH ACTIVE COVID 19 INFECTION GRAM NEGATIVE SEPSIS ALONG WITH RENAL REPLACEMENT THERAPY USING PMMA FILTER. RESULT(S) SIGNIFICANT IMPROVEMENT IN HEMODYNAMICS, DECREASED VASOPRESSOR REQIUREMENT, RAPILDLY RECOVERED FROM SEPSIS AND SHOCK CONCLUSION(S) This case report highlights the efficacy of a new adsorptive therapy for the clearance of endotoxins in septic shock caused Gram negative bacterial infection. Early application of an endotoxin adsorber showed a reduction of vasopressor requirements, elevation of blood pressure, and a decrease in inflammatory markers. Endotoxin elimination has a significant effect on the ICU length of stay or ICU mortality.