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Quantitative measurement of the SARS-CoV-2 IgG antibody and surrogate neutralizing antibody responses among mRNA COVID-19 vaccine-inoculated medical staff in designated medical institutions for infectious diseases
Journal of the Japanese Association for Infectious Diseases ; 96(2):52-55, 2022.
Article in Japanese | GIM | ID: covidwho-2203542
ABSTRACT
This study was aimed at evaluating the changes in the antibody titers and neutralization ability before and after inoculation with an mRNA COVID-19 vaccine (Pfizer, USA) among healthcare professionals (HCPs) in Japan. A total of 221 HCPs were enrolled and their blood samples were collected at three time points (1) before vaccination, (2) 3 weeks after the first dose, and (3) 3 weeks after the second dose. The titers of anti-SARS-CoV-2 Spike protein IgG antibody were measured in all the samples using VITROS-Anti-SARS-CoV-2 S1 Quant IgG Antibody (CLEIA, Ortho-Clinical Diagnostics, Inc.), and the surrogate Virus Neutralization Test (sVNT) (ELISA, GenScript, USA) was performed in the samples obtained after the vaccination. The anti-SARS-CoV-2 IgG titers were (1) median 0.16;Interquartile (IQR) 0.10-0.27, (2) median 250;IQR 99.5-466 and (3) median 2,400;IQR 1,480-3,950, respectively, at the three time-points. Our study also revealed the relationship between the anti-SARS-CoV-2 IgG antibody titer and the antibody neutralization activity.
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Full text: Available Collection: Databases of international organizations Database: GIM Topics: Vaccines Language: Japanese Journal: Journal of the Japanese Association for Infectious Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: GIM Topics: Vaccines Language: Japanese Journal: Journal of the Japanese Association for Infectious Diseases Year: 2022 Document Type: Article