Monthly transthoracic echocardiography in young adults for 6 months following SARS-CoV-2 infection.
Physiol Rep
; 11(1): e15560, 2023 01.
Article
in English
| MEDLINE | ID: covidwho-2204043
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit acute and long-term effects on the myocardium among survivors, yet effects among otherwise healthy young adults remains unclear. Young adults with mild symptoms of SARS-CoV-2 (8M/8F, age 21 ± 1 years, BMI 23.5 ± 3.1 kg·m-2 ) underwent monthly transthoracic echocardiography (TTE) and testing of circulating cardiac troponin-I for months 1-6 (M1-M6) following a positive polymerase chain reaction test to better understand the acute effects and post-acute sequelae of SARS-CoV-2 on cardiac structure and function. Left heart structure and ejection fraction were unaltered from M1-M6 (p > 0.05). While most parameters of septal and lateral wall velocities, mitral and tricuspid valve, and pulmonary vein (PV) were unaltered from M1-M6 (p > 0.05), lateral wall s' wave velocity increased (M1 0.113 ± 0.019 m·s-1 , M6 0.135 ± 0.022 m·s-1 , p = 0.013); PV S wave velocity increased (M1 0.596 ± 0.099 m·s-1 , M6 0.824 ± 0.118 m·s-1 , p < 0.001); the difference between PV A wave and mitral valve (MV) A wave durations decreased (M1 39.139 ± 43.715 ms, M6 18.037 ± 7.227 ms, p = 0.002); the ratio of PV A duration to MV A duration increased (M1 0.844 ± 0.205, M6 1.013 ± 0.132, p = 0.013); and cardiac troponin-I levels decreased (M1 0.38 ± 0.20 ng·ml-1 , M3 0.28 ± 0.34 ng·ml-1 , M6 0.29 ± 0.16 ng·ml-1 ; p = 0.002) over time. While young adults with mild symptoms of SARS-CoV-2 lacked changes to cardiac structure, the subclinical improvements to cardiac function and reduced inflammatory marker of cardiac troponin-I over 6 months following SARS-CoV-2 infection provide physiologic guidance to post-acute sequelae and recovery from SARS-CoV-2 and its variants using conventional TTE.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
/
Variants
Limits:
Adult
/
Humans
/
Young adult
Language:
English
Journal:
Physiol Rep
Year:
2023
Document Type:
Article
Affiliation country:
Phy2.15560
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