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Specific Clinical and Immunological Changes Following Mesenchymal Stem Cell Transplantation in COVID-19-induced Acute Respiratory Distress Syndrome Patients: A Phase-I Clinical Trial.
Kaffash Farkhad, Najmeh; Sedaghat, Alireza; Reihani, Hamidreza; Adhami Moghadam, Amir; Bagheri Moghadam, Ahmad; Khadem Ghaebi, Nayereh; Khodadoust, Mohammad Ali; Nikpoor, Amin Reza; Tavakol Afshari, Jalil.
  • Kaffash Farkhad N; Department of Immunology, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. kaffashn971@mums.ac.ir.
  • Sedaghat A; Lung Disease Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Sedaghatar@mums.ac.ir.
  • Reihani H; Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ReihaniHR@mums.ac.ir.
  • Adhami Moghadam A; Department of Internal Medicine and Critical Care, Islamic Azad University, Mashhad, Iran. Amir.Adhami58@Yahoo.com.
  • Bagheri Moghadam A; Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. bagheria@mums.ac.ir.
  • Khadem Ghaebi N; Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. KhademN@mums.ac.ir.
  • Khodadoust MA; Department of Immunology, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. khodadoustm1@mums.ac.ir.
  • Nikpoor AR; Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. nikpoora@gmail.com.
  • Tavakol Afshari J; Department of Immunology, Immunology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Tavakolaj@mums.ac.ir.
Iran J Allergy Asthma Immunol ; 21(6): 687-703, 2022 Dec 24.
Article in English | MEDLINE | ID: covidwho-2204584
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a systemic inflammation resulting from immune system overactivity. ARDS is also a fatal complication of COVID-19. Mesenchymal stem cells (MSCs) have immune modulatory properties. This study evaluated the safety and efficacy of three times transplantation of umbilical cord-derived MSCs (UC-MSCs) in terms of specific immunological and clinical changes in mild-to-moderate COVID-19-induced ARDS patients. In this single-center, open-label, phase 1 clinical trial, 20 patients diagnosed with COVID-19 and mild-to-moderate ARDS were included and were divided into two groups a control group receiving standard care and an intervention group receiving UC-MSC in addition to standard care. Three consecutive intravenous transplants of UC-MSC (1×  cells/kg body weight per each transplant) were performed in the intervention group on days 1, 3, and 5. The biological assay was investigated four times (days 0, 5, 10, and 17). UC-MSCs improved the patients' clinical and paraclinical parameters, including leukocytosis, lymphopenia, thrombocytopenia, and liver enzyme abnormalities compared to the control group. They also decreased pro-inflammatory lymphocytes (TH1 and TH17) and increased anti-inflammatory T lymphocytes. Cell therapy also reduced the mean fluorescence intensity (MFI) in overactivated CD8+ T cells.  These findings show that three UC-MSC injections could regulate a hyperactivated immune system in COVID-19-induced ARDS patients by decreasing the inflammatory T lymphocyte subset and can improve the patient's hematological condition and liver function. However, more studies are needed in this area.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Iran J Allergy Asthma Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: Ijaai.v21i6.11530

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Iran J Allergy Asthma Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: Ijaai.v21i6.11530