Clinical Risk Factors of Need for Intensive Care Unit Ad- mission of COVID-19 Patients, a Cross-sectional Study

ABSTRACT

Introduction: It could be beneficial to accelerate the hospitalization of patients with the identified clinical risk factors of intensive care unit (ICU) admission, in order to control and reduce COVID-19-related mortality. This study aimed to determine the clinical risk factors associated with ICU hospitalization of COVID-19 patients. Methods: The current research was a cross-sectional study. The study recruited 7182 patients who had positive PCR tests between February 23, 2020, and September 7, 2021 and were admitted to Afzalipour Hospital in Kerman, Iran, for at least 24 hours. Their demo-graphic characteristics, underlying diseases, and clinical parameters were collected. In order to analyze the relationship between the studied variables and ICU admission, multiple logistic regression model, classification tree, and support vector machine were used. Results: It was found that 14.7 percent (1056 patients) of the study participants were admit-ted to ICU. The patients' average age was 51.25 +/- 21 years, and 52.8% of them were male. In the study, some factors such as decreasing oxygen saturation level (OR=0.954, 95%CI 0.944-0.964), age (OR=1.007, 95%CI 1.004-1.011), respiratory distress (OR=1.658, 95%CI 1.410-1.951), reduced level of consciousness (OR=2.487, 95%CI 1.721-3.596), hypertension (OR=1.249, 95%CI 1.042-1.496), chronic pulmonary disease (OR=1.250, 95%CI 1.006-1.554), heart diseases (OR=1.250, 95%CI 1.009-1.548), chronic kidney disease (OR=1.515, 95%CI 1.111-2.066), cancer (OR=1.682, 95%CI 1.130-2.505), seizures (OR=3.428, 95%CI 1.615-7.274), and gender (OR=1.179, 95%CI 1.028-1.352) were found to significantly affect ICU admissions. Conclusion: As evidenced by the obtained results, blood oxygen saturation level, the patient's age, and their level of consciousness are crucial for ICU admission.