The Predictors of in-Hospital Mortality in Hypertensive Elderly Intensive Care Unit Patients with Coronavirus Disease 2019

ABSTRACT

Introduction: Advanced age is an important prognostic indicator for the mortality of coronavirus disease 2019, especially in patients over 65. Patients with chronic underlying conditions such as hypertension showed the worst outcomes. This study aimed to identify predictors of mortality in elderly hypertensive patients hospitalized in intensive care units. Material(s) and Method(s) Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records and compared between survivors and non-survivors. Univariate and multivariate logistic regression methods were used to explore the indicators of in-hospital mortality. Result(s) One hundred and ninety-eight patients with a median age of 75 years (65-94 years) were included in this study, of whom 95 were discharged from the intensive care units, and 103 died. Shortness of breath [hazard ratio (HR) 1.65, 95% confidence interval (CI) 1.04-2.61, p 0.034], C-reactive protein (CRP)/albumin ratio (>51.32) (HR 1.83, 95% CI 1.12-2.97, p 0.015), serum creatinine (>1.62 mg/dl) (HR 2.04, 95% CI 1.13-3.33, p 0.001), aspartate transaminase (>34 u/l) (HR 1.99, 95% CI 1.28-3.09, p 0.002), D-dimer (>781 ng/ml) (HR 1.59, 95% CI 1.04-2.43, p 0.031), leukocyte (>12,000' 103/microl) (HR 1.68, 95% CI 1.09-2.59, p 0.018) and lymphocyte count, (<=660' 103/microl) (HR 1.76, 95% CI 1.17-2.63, p 0.006) were independent predictors for mortality in elderly hypertensive patients. Conclusion(s) Using these predictors with cut-off values can identify patients at risk of death and needing aggressive intervention earlier in the disease course. Copyright © 2022, Geriatrics Society. All rights reserved.