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Possible Therapeutic Targets from Derivatives of Natural Marine Products Based on PI3K/AKT Dependent Inhibitors in Viral Infection COVID-19.
Aleebrahim-Dehkordi, Elahe; Koochaki, Pooneh; Samami, Elham; Ghoshouni, Hamed; Ghadimi, Delaram J; Shadnoush, Farnosh; Saberianpour, Shirin; Rafieian-Kopaei, Mahmoud.
  • Aleebrahim-Dehkordi E; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran, elahe.aleebrahim@gmail.com.
  • Koochaki P; Nutritional Health Team (NHT), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Samami E; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  • Ghoshouni H; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Ghadimi DJ; University of Florida Health Cancer Center, Gainesville, FL, USA.
  • Shadnoush F; University of Florida, College of Nursing, Gainesville, FL, USA.
  • Saberianpour S; Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Rafieian-Kopaei M; Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cell Physiol Biochem ; 56(6): 707-729, 2022 Dec 20.
Article in English | MEDLINE | ID: covidwho-2206081
ABSTRACT
Natural resources have long played a prominent part in conventional treatments as a parental source due to their multifaceted functions and lesser side effects. The diversity of marine products is a significant source of possible bioactive chemical compounds with a wide range of potential medicinal applications. Marine organisms produce natural compounds and new drugs with unique properties are produced from these compounds. A lot of bioactive compounds with medicinal properties are extracted from marine invertebrates, including Peptides, Alkaloids, Terpenoids, Steroids. Thus, it can be concluded that marine ecosystems are endowed with natural resources that have a wide range of medicinal properties, and it is important to examine the therapeutic and pharmacological capabilities of these molecules. So, finding particular inhibitors of the COVID-19 in natural compounds will be extremely important. Natural ingredients, in this light, could be a valuable resource in the progression of COVID-19 therapeutic options. Controlling the immunological response in COVID-19 patients may be possible by addressing the PI3K/Akt pathway and regulating T cell responses. T cell effector activity can be improved by preventing anti-viral exhaustion by suppressing PI3K and Akt during the early anti-viral response. The diversity of marine life is a significant supply of potentially bioactive chemical compounds with a broad range of medicinal uses. In this study, some biologically active compounds from marine organisms capable of inhibiting PI3K/AKT and the possible therapeutic targets from these compounds in viral infection COVID-19 have been addressed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / COVID-19 Limits: Humans Language: English Journal: Cell Physiol Biochem Journal subject: Biochemistry / Pharmacology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / COVID-19 Limits: Humans Language: English Journal: Cell Physiol Biochem Journal subject: Biochemistry / Pharmacology Year: 2022 Document Type: Article