Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19.

Agarwal, Sangya; June, Carl H

Agarwal, Sangya; June, Carl H.

Agarwal S; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania.
June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania. cjune@upenn.edu.

Cancer Discov ; 10(6): 775-778, 2020 06.

Article in English | MEDLINE | ID: covidwho-220615

ABSTRACT

ABSTRACT

Cytokine release and macrophage activation contribute to immunopathology after SARS-CoV-2 infection. We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy.

Subject(s)

Betacoronavirus; Coronavirus Infections/complications; Immunotherapy/methods; Inflammation/therapy; Pneumonia, Viral/complications; Animals; COVID-19; Calcineurin Inhibitors/therapeutic use; Cell- and Tissue-Based Therapy; Coronavirus Infections/epidemiology; Cytokines/metabolism; Drug Repositioning; Humans; Inflammation/epidemiology; Inflammation/etiology; Lymphohistiocytosis, Hemophagocytic/etiology; Lymphohistiocytosis, Hemophagocytic/prevention & control; Lymphohistiocytosis, Hemophagocytic/therapy; Macrophage Activation; Morbidity; Neoplasms/therapy; Neoplasms/virology; Pandemics; Pneumonia, Viral/epidemiology; Receptors, Antigen, T-Cell/immunology; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Immunotherapy / Inflammation Type of study: Observational study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Cancer Discov Year: 2020 Document Type: Article

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