A Study of Prevalence of Igg Antibodies against Covid 19 in Maternal and Cord Blood

ABSTRACT

Introduction: The pandemic of COVID-19 has spread a wave of insecurity, fear and anxiety because of unknown facts about the pathogen. To have a better understanding about this infection, a systematic study is required by the principles of epidemiology with detailed investigations and researches from different angles. Hence, we are undertaking the study of sero prevalence of IgG antibody to get the idea about herd immunity in pregnant patients coming for delivery and their newborns. Objective(s) To find out the correlation between subclinical attack/ mild attack of COVID 19 in the antenatal period. Method(s) This Cross-sectional study was conducted after getting cleared from Board of Studies and Ethical committee. The study population was calculated to be of 500 serum samples of both mother and newborns each. Result(s) The maternal age was 20-25 years among 179 (35.8%), 26-30 years among 129 (25.8%), 31-35 years among 118 (23.6%) and > 35 years among 74 (14.8%)patients. The maternal gestational age was 32-34 weeks among 59 (11.8%), 34.1-38 weeks among 98 (19.6%), 38.1-40 weeks among 275 (55.0%) and > 40 weeks among 68 (13.6%) patients. The Trimester with COVID-19 was 2nd among 152 (30.4%) and 3rd among 348 (69.6%) patients. IgG in mother at delivery was present among 59.0% mothers and IgG in cord blood was present among 54.0% newborns. Conclusion(s) Even at the time of diagnosis, aymptomatic pregnant women are able to reliably build a powerful IgG for receptor binding domain with neutralising response to COVID 19, as our results reveal. Although with opposition, majority of studies suggest that earlier the COVID 19 infection in pregnancy, better the transfer of IgG to fetus. As it is an evolving disease, extensive researches need to be established for a better result. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.