Recent outbreak of Marburg virus disease: Could it be a threat for global public health?

ABSTRACT

3 It has been linked to several outbreaks since its simultaneous identification and characterization in 1967 in Marburg and Frankfurt, Germany, as well as in Belgrade, Serbia. 4 A few documented cases of MVD have been reported in Africa from 1975 to 1985. [...]1998, MVD was not considered as fatal as the Ebola virus. Hemorrhagic fever syndromes though a crucial disease indication. Because they resembled more widespread illnesses like malaria and typhoid, early instances may be overlooked. There is currently no recognized vaccine or antiviral medication for treating MVD. 1 A few documented cases of MVD have been reported in Africa are undergoing Phase I, II, and III clinical studies. 12 A standardized literature review reported that antiviral drugs such as Galidesivir, Favipiravir, and Remdesivir showed promising results with an 83% to 100% success rate when the drugs are given at a specific dosage regimen. 2 Though their efficacy is not fully proven against a large population, their usage is not yet approved by the Food and Drug Administration (FDA) or any other authorized organization. 2 In brief, when the Marburg virus comes into human contact, it only takes a few days to cause a deathly situation, and effective treatment is not available yet. [...]it is more important to consider the outbreak of MVD as an alarming situation. There are some common overlapping symptoms of these three viral infections. [...]the global health-care authorities should develop and adopt differential diagnostic techniques for quick detection and isolation of cases.