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Torque teno virus (TTV): A gentle spy virus of immune status, predictive marker of seroconversion to COVID-19 vaccine in kidney and lung transplant recipients.
Roberto, Piergiorgio; Cinti, Lilia; Napoli, Anna; Paesani, Daniele; Riveros Cabral, Rodolfo J; Maggi, Fabrizio; Garofalo, Manuela; Pretagostini, Renzo; Centofanti, Anastasia; Carillo, Carolina; Venuta, Federico; Gaeta, Aurelia; Antonelli, Guido.
  • Roberto P; Department of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome, Italy.
  • Cinti L; Department of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome, Italy.
  • Napoli A; Department of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome, Italy.
  • Paesani D; INFN Frascati National Laboratory, Frascati, Italy.
  • Riveros Cabral RJ; Department of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome, Italy.
  • Maggi F; Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy.
  • Garofalo M; General Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
  • Pretagostini R; General Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
  • Centofanti A; Department of General and Specialistic Surgery "Paride Stefanini", Sapienza University of Rome, Rome, Italy.
  • Carillo C; Department of General and Specialistic Surgery "Paride Stefanini", Sapienza University of Rome, Rome, Italy.
  • Venuta F; Department of General and Specialistic Surgery "Paride Stefanini", Sapienza University of Rome, Rome, Italy.
  • Gaeta A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Antonelli G; Department of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome, Italy.
J Med Virol ; 95(2): e28512, 2023 02.
Article in English | MEDLINE | ID: covidwho-2209118
ABSTRACT
To date, no comprehensive marker to monitor the immune status of patients is available. Given that Torque teno virus (TTV), a known human virome component, has previously been identified as a marker of immunocompetence, it was retrospectively investigated whether TTV viral load may also represent a marker of ability to develop antibody in response to COVID-19-BNT162B2 vaccine in solid organ transplant recipients (SOT). Specifically, 273 samples from 146 kidney and 26 lung transplant recipients after successive doses of vaccine were analyzed. An inverse correlation was observed within the TTV copy number and anti-Spike IgG antibody titer with a progressive decrease in viremia the further away from the transplant date. Analyzing the data obtained after the second dose, a significant difference in TTV copy number between responsive and nonresponsive patients was observed, considering a 5 log10 TTV copies/mL threshold to discriminate between the two groups. Moreover, for 86 patients followed in their response to the second and third vaccination doses a 6 log10 TTV copies/mL threshold was used to predict responsivity to the booster dose. Although further investigation is necessary, possibly extending the analysis to other patient categories, this study suggests that TTV can be used as a good marker of vaccine response in transplant patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Torque teno virus / DNA Virus Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28512

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Torque teno virus / DNA Virus Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28512