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mRNA COVID-19 Vaccine Anaphylaxis: Epidemiology, Risk Factors, and Evaluation.
Jaggers, Jordon; Wolfson, Anna R.
  • Jaggers J; Harvard Medical School, Boston, MA, USA.
  • Wolfson AR; Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
Curr Allergy Asthma Rep ; 23(3): 195-200, 2023 03.
Article in English | MEDLINE | ID: covidwho-2209517
ABSTRACT
PURPOSE OF REVIEW The COVID-19 vaccines have proved essential in our defense against the COVID-19 pandemic. However, concerns regarding allergic reactions to the vaccines persist to this day. Herein, we review the data regarding the frequency of allergic reactions to the COVID-19 vaccines, the epidemiology, and the management of patients reporting vaccine allergic reactions. RECENT

FINDINGS:

Although initial reports emphasized a high risk of anaphylaxis to the COVID-19 vaccines, more recent data demonstrate similar rates of anaphylaxis to the COVID-19 vaccines as to other vaccines. Alternative explanations for increased rates of apparent allergic reactions are discussed, including the role for stress-related and nocebo responses. COVID-19 vaccines and mRNA vaccine technology are overwhelmingly safe and well-tolerated by most patients. Careful history and case review will enable the discerning physician to safely vaccinate most patients. Rare patients with objective signs and symptoms of anaphylaxis may be candidates for alternatives to vaccination including monoclonal antibodies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Anaphylaxis Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Curr Allergy Asthma Rep Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: S11882-023-01065-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Anaphylaxis Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Curr Allergy Asthma Rep Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: S11882-023-01065-2