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Anti-SARS-CoV-2 cellular response after 2 and 3 doses of BNT162b2 mRNA vaccine in lymphoma patients receiving anti-CD20 antibodies.
Gressens, Simon B; Wiedemann, Aurélie; Déchenaud, Marie; Dupuis, Jehan; Gallien, Sébastien; Melica, Giovanna; Haioun, Corinne; Lemonnier, François; Levy, Yves.
  • Gressens SB; Infectious Diseases and Immunology Department, Hôpital Universitaire Henri Mondor, Assistance Publique Hôpitaux de Paris - Université Paris Est Créteil, France. Electronic address: simon.gressens@aphp.fr.
  • Wiedemann A; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, Team 16, Créteil, France; Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France.
  • Déchenaud M; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, Team 16, Créteil, France.
  • Dupuis J; IAP-HP, Groupe hospitalo-universitaire Chenevier Mondor, Service Unité Hémopathies Lymphoides, F-94010 Créteil, France.
  • Gallien S; Infectious Diseases and Immunology Department, Hôpital Universitaire Henri Mondor, Assistance Publique Hôpitaux de Paris - Université Paris Est Créteil, France; Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France.
  • Melica G; Infectious Diseases and Immunology Department, Hôpital Universitaire Henri Mondor, Assistance Publique Hôpitaux de Paris - Université Paris Est Créteil, France; Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France. Electronic address: giovanna.melica@aphp.fr.
  • Haioun C; IAP-HP, Groupe hospitalo-universitaire Chenevier Mondor, Service Unité Hémopathies Lymphoides, F-94010 Créteil, France; Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France.
  • Lemonnier F; IAP-HP, Groupe hospitalo-universitaire Chenevier Mondor, Service Unité Hémopathies Lymphoides, F-94010 Créteil, France; Univ Paris Est Créteil, INSERM, IMRB, F-94010 Créteil, France.
  • Levy Y; Infectious Diseases and Immunology Department, Hôpital Universitaire Henri Mondor, Assistance Publique Hôpitaux de Paris - Université Paris Est Créteil, France; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, Team 16, Créteil, France. Electronic address: y
Vaccine ; 41(9): 1550-1553, 2023 Feb 24.
Article in English | MEDLINE | ID: covidwho-2211626
ABSTRACT
Patients receiving anti-CD20 antibodies showed limited efficacy of a booster dose of BNT162b2. Patients with lymphomas combine such immunotherapies with cytotoxic chemotherapies that could result in an even greater alteration of the immune response to vaccination. We report here the impact of a third vaccine dose on T cell specific responses in a small cohort of patients treated in our center by anti-CD20 therapies and cytotoxic chemotherapies for lymphoid malignancies. Our results showed that a third dose in these severely immune suppressed patients could improve the expansion on CD4+Th1+T cell responses while the effect CD8 + T cell responses was marginal.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lymphoma Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Vaccine Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lymphoma Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Vaccine Year: 2023 Document Type: Article