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Comparing the SARS-CoV-2-specific antibody response in human milk after homologous and heterologous booster vaccinations.
Mulleners, Sien J; Juncker, Hannah G; Ruhé, Eliza J M; Korosi, Aniko; van Goudoever, Johannes B; van Gils, Marit J; van Keulen, Britt J.
  • Mulleners SJ; Emma Children's Hospital, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Center (location VUmc), De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.
  • Juncker HG; Emma Children's Hospital, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Center (location VUmc), De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.
  • Ruhé EJM; Swammerdam Institute for Life Sciences, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
  • Korosi A; Emma Children's Hospital, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Center (location VUmc), De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.
  • van Goudoever JB; Swammerdam Institute for Life Sciences, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
  • van Gils MJ; Emma Children's Hospital, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Center (location VUmc), De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands. h.vangoudoever@amsterdamumc.nl.
  • van Keulen BJ; Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center (location AMC), Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Commun Biol ; 6(1): 100, 2023 01 25.
Article in English | MEDLINE | ID: covidwho-2212036
ABSTRACT
Human milk contains SARS-CoV-2-specific antibodies after COVID-19 vaccination. These milk antibodies decrease several months post-vaccination. Whether booster immunization restores human milk antibody levels, potentially offering prolonged passive immunity for the infant, remains unknown. In this prospective follow-up study, we investigated the longitudinal SARS-CoV-2-specific antibody response in human milk of 26 lactating women who received a COVID-19 booster dose of an mRNA-based vaccine. Moreover, we evaluated whether the booster-induced human milk antibody response differs for participants who received a similar or different vaccine type in their primary vaccination series. All participants (100%) who received a homologous booster vaccination showed SARS-CoV-2-specific immunoglobulin A (IgA) and immunoglobulin G (IgG) in their milk. Heterologous booster vaccination resulted in milk conversion for 9 (69%) and 13 (100%) participants for IgA and IgG respectively. Findings of this study indicate that both homologous and heterologous boosting schedules have the potential to enhance SARS-CoV-2-specific IgA and IgG in human milk.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Milk, Human Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant Language: English Journal: Commun Biol Year: 2023 Document Type: Article Affiliation country: S42003-023-04455-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Milk, Human Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant Language: English Journal: Commun Biol Year: 2023 Document Type: Article Affiliation country: S42003-023-04455-4