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A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.
Søndergaard, Jonas Nørskov; Tulyeu, Janyerkye; Edahiro, Ryuya; Shirai, Yuya; Yamaguchi, Yuta; Murakami, Teruaki; Morita, Takayoshi; Kato, Yasuhiro; Hirata, Haruhiko; Takeda, Yoshito; Okuzaki, Daisuke; Sakaguchi, Shimon; Kumanogoh, Atsushi; Okada, Yukinori; Wing, James Badger.
  • Søndergaard JN; Human Immunology Team, Center for Infectious Disease Education and Research, Osaka University, Suita 565-0871, Japan.
  • Tulyeu J; Human Immunology Team, Center for Infectious Disease Education and Research, Osaka University, Suita 565-0871, Japan.
  • Edahiro R; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Shirai Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Yamaguchi Y; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Murakami T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Morita T; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Kato Y; Department of Immunopathology, World Premier International Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan.
  • Hirata H; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Takeda Y; Department of Immunopathology, World Premier International Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan.
  • Okuzaki D; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Sakaguchi S; Department of Immunopathology, World Premier International Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan.
  • Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
  • Okada Y; Department of Immunopathology, World Premier International Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan.
  • Wing JB; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Proc Natl Acad Sci U S A ; 120(4): e2217902120, 2023 Jan 24.
Article in English | MEDLINE | ID: covidwho-2212237
ABSTRACT
Sex-biased humoral immune responses to COVID-19 patients have been observed, but the cellular basis for this is not understood. Using single-cell proteomics by mass cytometry, we find disrupted regulation of humoral immunity in COVID-19 patients, with a sex-biased loss of circulating follicular regulatory T cells (cTfr) at a significantly greater rate in male patients. In addition, a male sex-associated cellular network of T-peripheral helper, plasma blasts, proliferating and extrafollicular/atypical CD11c+ memory B cells was strongly positively correlated with neutralizing antibody concentrations and negatively correlated with cTfr frequency. These results suggest that sex-specific differences to the balance of cTfr and a network of extrafollicular antibody production-associated cell types may be a key factor in the altered humoral immune responses between male and female COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Antibody Formation Limits: Female / Humans / Male Language: English Journal: Proc Natl Acad Sci U S A Year: 2023 Document Type: Article Affiliation country: Pnas.2217902120

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Antibody Formation Limits: Female / Humans / Male Language: English Journal: Proc Natl Acad Sci U S A Year: 2023 Document Type: Article Affiliation country: Pnas.2217902120