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Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.
Rocco, Joseph M; Laghetti, Paola; Di Stefano, Mariantonietta; Sereti, Irini; Ortega-Villa, Ana; Wang, Jing; Rupert, Adam; Chironna, Maria; Ye, Lara; Liu, Xiangdong; Anderson, Megan V; Burbelo, Peter B; Fiore, Jose Ramon; Saracino, Annalisa; Lisco, Andrea.
  • Rocco JM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Laghetti P; Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari, Bari, Italy.
  • Di Stefano M; Section of Pharmacology, Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy.
  • Sereti I; Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, Foggia, Italy.
  • Ortega-Villa A; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Wang J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Rupert A; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Chironna M; Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
  • Ye L; Hygiene Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
  • Liu X; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Anderson MV; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Burbelo PB; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Fiore JR; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
  • Saracino A; Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, Foggia, Italy.
  • Lisco A; Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari, Bari, Italy.
Open Forum Infect Dis ; 9(9): ofac427, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-2212860
ABSTRACT
In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid