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Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals.
von Borstel, Anouk; Nguyen, Thi Ho; Rowntree, Louise C; Ashhurst, Thomas M; Allen, Lilith F; Howson, Lauren J; Holmes, Natasha E; Smibert, Olivia C; Trubiano, Jason A; Gordon, Claire L; Cheng, Allen C; Kent, Stephen J; Rossjohn, Jamie; Kedzierska, Katherine; Davey, Martin S.
  • von Borstel A; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Nguyen TH; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Rowntree LC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Ashhurst TM; Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, Australia.
  • Allen LF; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia.
  • Howson LJ; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Holmes NE; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Smibert OC; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.
  • Trubiano JA; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia.
  • Gordon CL; Data Analytics Research and Evaluation (DARE) Centre, Austin Health and University of Melbourne, Heidelberg, VIC, Australia.
  • Cheng AC; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.
  • Kent SJ; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.
  • Rossjohn J; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
  • Kedzierska K; National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
  • Davey MS; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.
Immunol Cell Biol ; 101(4): 321-332, 2023 04.
Article in English | MEDLINE | ID: covidwho-2213646
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27neg CD45RA+ CX3CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocyte Subsets / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Immunol Cell Biol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: Imcb.12623

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocyte Subsets / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Immunol Cell Biol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: Imcb.12623