Your browser doesn't support javascript.
Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2022.
Winthrop, Kevin L; Isaacs, John D; Mease, Philip J; Boumpas, Dimitrios T; Baraliakos, Xenofon; Gottenberg, Jacques-Eric; Siebert, Stefan; Mosca, Marta; Basu, Neil; Orange, Dana; Lories, R; Aletaha, Daniel; McInnes, Iain B; Huizinga, Tom W J; Voll, Reinhard E; Gravallese, Ellen M; Breedveld, Ferry C; Smolen, Josef S.
  • Winthrop KL; Department of Medicine, Oregon Health and Sciences University (OHSU), Portland, Oregon, USA winthrop@ohsu.edu.
  • Isaacs JD; Department of Clinical Rheumatology, Newcastle University, Newcastle upon Tyne, UK.
  • Mease PJ; Swedish Medical Center; University of Washington, Seattle, Washington, USA.
  • Boumpas DT; 4th Department of Internal Medicine, Rheumatology and Clinical Immunology Unit, National and Kapodistrian University of Athens, Athens, Greece.
  • Baraliakos X; Ruhr-University Bochum, Rheumazentrum Ruhrgebiet Herne, Herne, Germany.
  • Gottenberg JE; Centre National de Référence des Maladies AutoImmunes Systémiques Rares CHU Strasbourg-Hautepierre, Strasbourg, France.
  • Siebert S; College of Medical, Veterinary & Life Sciences; University of Glasgow, Glasgow, UK.
  • Mosca M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Basu N; College of Medical, Veterinary & Life Sciences; University of Glasgow, Glasgow, UK.
  • Orange D; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Lories R; Division of Rheumatology Hospital for Special Surgery, New York, NY, USA.
  • Aletaha D; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Wien, Austria.
  • McInnes IB; College of Medical, Veterinary & Life Sciences; University of Glasgow, Glasgow, UK.
  • Huizinga TWJ; Division of Rheumatology, University of Leuven, Leuven, The Netherlands.
  • Voll RE; Department of Rheumatology and Clinical Immunology, University of Freiburg, Freiburg, Germany.
  • Gravallese EM; Brigham and Women?s Hospital, Harvard University, Boston, Massachusetts, USA.
  • Breedveld FC; Department of Rheumatology, University of Leiden, Leiden, The Netherlands.
  • Smolen JS; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Wien, Austria.
Ann Rheum Dis ; 82(5): 594-598, 2023 05.
Article in English | MEDLINE | ID: covidwho-2213913
ABSTRACT
To detail the unmet clinical and scientific needs in the field of rheumatology. After a 2-year hiatus due to the SARS-CoV-2 pandemic, the 22nd annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. Breakout sessions were convened with experts in five rheumatological disease-specific groups including rheumatoid arthritis (RA), psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and connective tissue diseases (CTDs). In each group, experts were asked to identify and prioritise current unmet needs in clinical and translational research, as well as highlight recent progress in meeting formerly identified unmet needs. Clinical trial design innovation was emphasised across all disease states. Within RA, developing therapies and trials for refractory disease patients remained among the most important identified unmet needs and within lupus and spondyloarthritis the need to account for disease endotypes was highlighted. The RA group also identified the need to better understand the natural history of RA, pre-RA states and the need ultimately for precision medicine. In CTD generally, experts focused on the need to better identify molecular, cellular and clinical signals of early and undifferentiated disease in order to identify novel drug targets. There remains a strong need to develop therapies and therapeutic strategies for those with treatment-refractory disease. Increasingly it is clear that we need to better understand the natural history of these diseases, including their 'predisease' states, and identify molecular signatures, including at a tissue level, which can facilitate disease diagnosis and treatment. As these unmet needs in the field of rheumatic diseases have been identified based on consensus of expert clinicians and scientists in the field, this document may serve individual researchers, institutions and industry to help prioritise their scientific activities.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Rheumatology / Arthritis, Psoriatic / Rheumatic Diseases / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Ann Rheum Dis Year: 2023 Document Type: Article Affiliation country: Ard-2022-223528

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Rheumatology / Arthritis, Psoriatic / Rheumatic Diseases / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Ann Rheum Dis Year: 2023 Document Type: Article Affiliation country: Ard-2022-223528