Complications of COVID-19 on the thyroid gland functioning

ABSTRACT

Annotation Pandemics of coronoviral infection continues affecting the wold community, and with the comprehension of its pathological physiology an interest in endocrine effects of SARSCoV- 2 grows too. It was determined, that the main target organs affected by SARS-CoV-2 were lungs and immune system, while it is still not clear if SARS-CoV-2 has any impact on the thyroid function. In patients infected with SARS-CoV, coronovirus relevant to SARS-CoV-2, damage of parafollicular and follicular cells in thyroid glands was seen at autopsy. The Objective: To assess the consequent effect of Covid- 19viral infection on thyroid functions prior to operation period. Materials and Research Methods: While performing retrospective analysis we checked 110 case histories of patients receiving in-patient therapy in Vitamed clinic and Turakulov RSSPMC of Endocrinology from May 2020 to January 2021.We revealed 53 patients who recovered from Covid-19. We checked thyroid hormones (TTH, free T4, total T3), performed ultra sound imaging and histological test of thyroid gland, CBA, and biochemical tests. Result(s) Among 53 patients, who recovered from COVID-19, there were 40 (75%) women and 13 (25%) men. The age of the patients varied from 30 to 78 years old (average 52.6 years old). Eleven patients out of 53 complained discomfort at the frontal side of neck, dry skin, feeling of a lump in throat, loss of hair, weakness, and shortbreathing. Ultra sound imaging revealed presence of nodes. Histological tests showed, that 7 patients had thyroid cancer. Ultra sound showed, that six patients out of 11 had TI-RADS 4, four had TI-RADS 3, and one had TI-RADS 5.Histological tests revealed, that six patients out of 11 hadBETHESDA 4, two had BETHESDA 5, and two patients had histologically revealed BETHESDA 2.