Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver.
Pediatrics
; 151(2)2023 02 01.
Article
in English
| MEDLINE | ID: covidwho-2214881
ABSTRACT
As of June 15, 2022, the Centers for Disease Control and Prevention has reported 296 pediatric patients under investigation for hepatitis of unknown etiology in the United States; the World Health Organization has reported 650 probable cases worldwide. One of the leading hypotheses for this cluster of cases is adenovirus, a virus that commonly causes respiratory or gastrointestinal symptoms in healthy children but rarely causes severe hepatitis or acute liver failure in immunocompetent children. The other leading hypothesis is that prior infection with SARS-CoV-2 may predispose children to developing liver injury from a normally innocuous agent. We describe a case of a previously healthy child presenting with acute liver failure who had detectable adenovirus DNA in his stool, whole blood, and in liver explant tissue, suggesting adenovirus as the likely etiology for the liver failure. He had no evidence of prior or current SARS-CoV-2 infection, nor had he received COVID vaccination, suggesting that SARS-CoV-2 did not play a role. Additionally, we report on the ability to provide rapid evaluation of a living donor within 72 hours and successfully perform a lifesaving, left-lobe, living donor liver transplant.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Liver Failure, Acute
/
Adenoviridae Infections
/
COVID-19
Type of study:
Case report
/
Diagnostic study
/
Etiology study
/
Experimental Studies
/
Observational study
Topics:
Long Covid
/
Vaccines
Limits:
Child
/
Humans
/
Male
Language:
English
Year:
2023
Document Type:
Article
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