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Genetic Manipulation in Mucorales and New Developments to Study Mucormycosis.
Lax, Carlos; Cánovas-Márquez, José Tomás; Tahiri, Ghizlane; Navarro, Eusebio; Garre, Victoriano; Nicolás, Francisco Esteban.
  • Lax C; Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
  • Cánovas-Márquez JT; Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
  • Tahiri G; Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
  • Navarro E; Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
  • Garre V; Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
  • Nicolás FE; Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
Int J Mol Sci ; 23(7)2022 Mar 22.
Article in English | MEDLINE | ID: covidwho-2216277
ABSTRACT
The study of the Mucoralean fungi physiology is a neglected field that the lack of effective genetic tools has hampered in the past. However, the emerging fungal infection caused by these fungi, known as mucormycosis, has prompted many researchers to study the pathogenic potential of Mucorales. The main reasons for this current attraction to study mucormycosis are its high lethality, the lack of effective antifungal drugs, and its recent increased incidence. The most contemporary example of the emergence character of mucormycosis is the epidemics declared in several Asian countries as a direct consequence of the COVID-19 pandemic. Fortunately, this pressure to understand mucormycosis and develop new treatment strategies has encouraged the blossoming of new genetic techniques and methodologies. This review describes the history of genetic manipulation in Mucorales, highlighting the development of methods and how they allowed the main genetic studies in these fungi. Moreover, we have emphasized the recent development of new genetic models to study mucormycosis, a landmark in the field that will configure future research related to this disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mucorales / Mucormycosis Type of study: Observational study / Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23073454

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mucorales / Mucormycosis Type of study: Observational study / Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23073454