Your browser doesn't support javascript.
The One-Hundred-Year Anniversary of the Discovery of the Sunshine Vitamin D3: Historical, Personal Experience and Evidence-Based Perspectives.
Holick, Michael F.
  • Holick MF; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Nutrients ; 15(3)2023 Jan 23.
Article in English | MEDLINE | ID: covidwho-2216672
ABSTRACT
The discovery of a fat-soluble nutrient that had antirachitic activity and no vitamin A activity by McCollum has had far reaching health benefits for children and adults. He named this nutrient vitamin D. The goal of this review and personal experiences is to give the reader a broad perspective almost from the beginning of time for how vitamin D evolved to became intimately involved in the evolution of land vertebrates. It was the deficiency of sunlight causing the devastating skeletal disease known as English disease and rickets that provided the first insight as to the relationship of sunlight and the cutaneous production of vitamin D3. The initial appreciation that vitamin D could be obtained from ultraviolet exposure of ergosterol in yeast to produce vitamin D2 resulted in the fortification of foods with vitamin D2 and the eradication of rickets. Vitamin D3 and vitamin D2 (represented as D) are equally effective in humans. They undergo sequential metabolism to produce the active form of vitamin D, 1,25-dihydroxyvitamin D. It is now also recognized that essentially every tissue and cell in the body not only has a vitamin D receptor but can produce 1,25-dihydroxyvitamin D. This could explain why vitamin D deficiency has now been related to many acute and chronic illnesses, including COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Rickets / Vitamin D Deficiency / Cholecalciferol Type of study: Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Animals / Child / Humans Language: English Year: 2023 Document Type: Article Affiliation country: Nu15030593

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Rickets / Vitamin D Deficiency / Cholecalciferol Type of study: Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Animals / Child / Humans Language: English Year: 2023 Document Type: Article Affiliation country: Nu15030593