ZDHHC11 Suppresses Zika Virus Infections by Palmitoylating the Envelope Protein.
Viruses
; 15(1)2023 Jan 02.
Article
in English
| MEDLINE | ID: covidwho-2216942
ABSTRACT
Zika virus (ZIKV) is an RNA-enveloped virus that belongs to the Flavivirus genus, and ZIKV infections potentially induce severe neurodegenerative diseases and impair male fertility. Palmitoylation is an important post-translational modification of proteins that is mediated by a series of DHHC-palmitoyl transferases, which are implicated in various biological processes and viral infections. However, it remains to be investigated whether palmitoylation regulates ZIKV infections. In this study, we initially observed that the inhibition of palmitoylation by 2-bromopalmitate (2-BP) enhanced ZIKV infections, and determined that the envelope protein of ZIKV is palmitoylated at Cys308. ZDHHC11 was identified as the predominant enzyme that interacts with the ZIKV envelope protein and catalyzes its palmitoylation. Notably, ZDHHC11 suppressed ZIKV infections in an enzymatic activity-dependent manner and ZDHHC11 knockdown promoted ZIKV infection. In conclusion, we proposed that the envelope protein of ZIKV undergoes a novel post-translational modification and identified a distinct mechanism in which ZDHHC11 suppresses ZIKV infections via palmitoylation of the ZIKV envelope protein.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Flavivirus
/
Zika Virus
/
Zika Virus Infection
Limits:
Humans
/
Male
Language:
English
Year:
2023
Document Type:
Article
Affiliation country:
V15010144
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