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ZDHHC11 Suppresses Zika Virus Infections by Palmitoylating the Envelope Protein.
Hu, Dingwen; Zou, Haimei; Chen, Weijie; Li, Yuting; Luo, Ziqing; Wang, Xianyang; Guo, Dekuan; Meng, Yu; Liao, Feng; Wang, Wenbiao; Zhu, Ying; Wu, Jianguo; Li, Geng.
  • Hu D; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Zou H; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
  • Chen W; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou 510632, China.
  • Li Y; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Luo Z; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Wang X; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Guo D; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Meng Y; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Liao F; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Wang W; Medical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
  • Zhu Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Wu J; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • Li G; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou 510632, China.
Viruses ; 15(1)2023 Jan 02.
Article in English | MEDLINE | ID: covidwho-2216942
ABSTRACT
Zika virus (ZIKV) is an RNA-enveloped virus that belongs to the Flavivirus genus, and ZIKV infections potentially induce severe neurodegenerative diseases and impair male fertility. Palmitoylation is an important post-translational modification of proteins that is mediated by a series of DHHC-palmitoyl transferases, which are implicated in various biological processes and viral infections. However, it remains to be investigated whether palmitoylation regulates ZIKV infections. In this study, we initially observed that the inhibition of palmitoylation by 2-bromopalmitate (2-BP) enhanced ZIKV infections, and determined that the envelope protein of ZIKV is palmitoylated at Cys308. ZDHHC11 was identified as the predominant enzyme that interacts with the ZIKV envelope protein and catalyzes its palmitoylation. Notably, ZDHHC11 suppressed ZIKV infections in an enzymatic activity-dependent manner and ZDHHC11 knockdown promoted ZIKV infection. In conclusion, we proposed that the envelope protein of ZIKV undergoes a novel post-translational modification and identified a distinct mechanism in which ZDHHC11 suppresses ZIKV infections via palmitoylation of the ZIKV envelope protein.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Flavivirus / Zika Virus / Zika Virus Infection Limits: Humans / Male Language: English Year: 2023 Document Type: Article Affiliation country: V15010144

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Flavivirus / Zika Virus / Zika Virus Infection Limits: Humans / Male Language: English Year: 2023 Document Type: Article Affiliation country: V15010144