Digestive system infection by SARSCoV2: Entry mechanism, clinical symptoms and expression of major receptors (Review).
Int J Mol Med
; 51(3)2023 Mar.
Article
in English
| MEDLINE | ID: covidwho-2217153
ABSTRACT
Besides causing severe acute respiratory syndrome (SARS), SARScoronavirus 2 (SARSCoV2) also harms the digestive system. Given the appearance of numerous cases of SARSCoV2, it has been demonstrated that SARSCoV2 is able to harm target organs such as the gastrointestinal tract, liver and pancreas, and either worsen the condition of patients with basic digestive illnesses or make their prognosis poor. According to several previously published studies, angiotensinconverting enzyme II (ACE2) and transmembrane serine protease II (TMPRSS2) are expressed either singly or in combination in the digestive system and in other regions of the human body. In order to change the viral conformation, create a fusion hole and release viral RNA into the host cell for replication and transcription, SARSCoV2 is capable of binding to these two proteins through the spike protein on its surface. As a result, the body experiences an immune reaction and an inflammatory reaction, which may lead to nausea, diarrhea, abdominal pain and even gastrointestinal bleeding, elevated levels of liver enzymes, acute liver injury, pancreatitis and other serious lesions. In order to provide possible strategies for the clinical diagnosis and treatment of digestive system diseases during the COVID19 pandemic, the molecular structure of SARSCoV2 and the mechanism via which SARSCoV2 enters the human body through ACE2 and TMPRSS2 were discussed in the present review, and the clinical manifestations of SARSCoV2 infection in the digestive system were also summarized. Finally, the expression characteristics of ACE2 and TMPRSS2 in the main target organs of the digestive system were described.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Digestive System Diseases
/
COVID-19
Type of study:
Prognostic study
/
Qualitative research
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal subject:
Molecular Biology
/
Genetics, Medical
Year:
2023
Document Type:
Article
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