A Study To Assess The Correlation Of D Dimer Levels In Prediction Of The Need Of Renal Replacement Therapy In COVID Patients With Acute Kidney Injury

ABSTRACT

Coronavirus disease 2019 is predominantly a respiratory illness that can cause hypercoagulable states with multisystem involvement. A single centre retrospective study was carried out in 37 patients who were diagnosed as COVID 19 with AKI from January 2022 to march 2022. Baseline D dimer was evaluated on hospital admission. Patients who were diagnosed with AKI on admission or during the stay in hospital were included in the study, In this study 37 COVID patients with AKI were analysed. Mean age of subjects was 62.51+/-15.18 years. Majority were in the age group 61-70 years (24.3%). 78.4% were males and 21.6% were females. Mean blood urea among subjects was 131.86+/-56.55(mmol/L), mean serum creatinine was 4.71+/-2.52(mg/dl). mean d dimer at admission was 3.701+/-4.48570(mg/L).70.3% of subjects had AKI at hospital admission and 29.7% developed AKI during hospital stay. Cause of AKI was prerenal in 89.2%, renal 18.9%,and post renal in 8.1%. D dimer levels >3.05 had highest validity in predicting the need for RRT with sensitivity 39.29%, specificity 100%, positive predictive value of 100% and negative predictive value of 34.6%. from this study it was concluded that d dimer has specificity of 100%in predicting the need of RRT Copyright © 2023, Research Journal of Pharmaceutical, Biological and Chemical Sciences.All Rights Reserved.