A Study of Prevalence of Igg Antibodies against Covid 19 in Maternal and Cord Blood

ABSTRACT

Introduction: The pandemic of COVID-19 has spread a wave of insecurity, fear and anxiety because of unknown facts about the pathogen. To have a better understanding about this infection, a systematic study is required by the principles of epidemiology with detailed investigations and researches from different angles. Hence, we are undertaking the study of seroprevalence of IgG antibody to get the idea about herd immunity in pregnant patients coming for delivery and their newborns. Objective(s) To find out the correlation between subclinical attack / mild attack of COVID 19 in the antenatal period. Method(s) This Cross-sectional study was conducted after getting cleared from Board of Studies and Ethical committee. The study population was calculated to be of 500 serum samples of both mother and newborns each. Result(s) The maternal age was 20-25 years among 230 (36.0%), 26-30 years among 164 (32.8%), 31-35 years among 88 (17.6%) and > 35 years among 18 (3.6%) patients. The maternal gestational age was <37 weeks 0 days at the time of delivery in 82 (16.4%) and that of >= 37 weeks was 418 (83.6%) patients. The exposure of COVID 19 virus and/or even the asymptomatic carriers, led to a data showing 18% (90 patients) of the study population being affected in 2nd trimester, 48.6% (243 patients) in 3rd trimester and 33.4% (167 patients) not affected at all in the pregnancy. IgG in mother at delivery was present among 21.4 % mothers. IgG in cord blood was present among 12.0% newborns. Conclusion(s) Although even at the time of diagnosis, asymptomatic pregnant women are able to reliably build a powerful IgG for receptor binding domain with neutralising response to COVID 19, as our results reveal. In addition, our findings indicate that this reaction was long-lasting, which lends credence to the notion that immunisation in this population will be successful. And after extensive research studies, pregnant females were allowed to be vaccinated against COVID 19. Copyright © 2022 Authors. All rights reserved.