Your browser doesn't support javascript.
Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia.
Amrina, M A; Shahidah, M; Sofiah, H R; Mirlia, S C M; Thilakaveni, R; Chong, Z L; Mohd-Hatta, A M; Cheah, Y K; Aidalina, M; Niazlin, M T; Syafinaz, A N; Abdullah, M; Muhammad, M I.
  • Amrina MA; Universiti Putra Malaysia, Faculty of Medicine & Health Sciences, Department of Pathology, Selangor, Malaysia.
  • Shahidah M; Hospital Pengajar Universiti Putra Malaysia, Department of Medical Microbiology, Universiti Putra, Selangor, Malaysia.
  • Sofiah HR; Hospital Pengajar Universiti Putra Malaysia, Department of Pathology, Universiti Putra, Selangor, Malaysia.
  • Mirlia SCM; Hospital Pengajar Universiti Putra Malaysia, Department of Pathology, Universiti Putra, Selangor, Malaysia.
  • Thilakaveni R; Hospital Pengajar Universiti Putra Malaysia, Nursing Unit, Universiti Putra, Selangor, Malaysia.
  • Chong ZL; Institute for Public Health, Centre for Communicable Diseases Research, Ministry of Health, Malaysia.
  • Mohd-Hatta AM; Institute for Public Health, Centre for Communicable Diseases Research, Ministry of Health, Malaysia.
  • Cheah YK; Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Biomedical Sciences, Selangor, Malaysia.
  • Aidalina M; Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Community Health, Selangor, Malaysia.
  • Niazlin MT; Hospital Pengajar Universiti Putra Malaysia, Department of Medical Microbiology, Universiti Putra, Selangor, Malaysia.
  • Syafinaz AN; Universiti Putra Malaysia, Faculty of Medicine & Health Sciences, Department of Pathology, Selangor, Malaysia.
  • Abdullah M; Universiti Putra Malaysia, Faculty of Medicine & Health Sciences, Department of Pathology, Selangor, Malaysia.
  • Muhammad MI; Universiti Putra Malaysia, Faculty of Medicine & Health Sciences, Department of Ophthalmology, Selangor, Malaysia. mmi@upm.edu.my.
Med J Malaysia ; 78(1): 20-24, 2023 01.
Article in English | MEDLINE | ID: covidwho-2218443
ABSTRACT

INTRODUCTION:

Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated with mRNA vaccine (BTN162b2) and inactivated vaccine (CoronaVac). MATERIALS AND

METHODS:

Plasma samples were collected prevaccination, 2 weeks and 6 months post-vaccination and tested for total immunoglobulin levels using ELISA method.

RESULTS:

A small percentage of HCW (2.2%, 15/677) had elevated anti-S antibody levels in their pre-vaccination plasma samples (median 20.4, IQR 5.8), indicating that they were exposed to SARS-CoV-2 infection prior to vaccination. The mRNA vaccine significantly increased anti-S levels of both previously infected and uninfected individuals to saturation levels (median 21.88, IQR.0.88) at 2 weeks postsecond dose of the vaccine. At 6 months post-vaccination, the antibody levels appeared to be maintained among the recipients of the mRNA vaccine. However, at this time point, anti-S antibody levels were lower in individuals given inactivated vaccine (median 20.39, IQR 7.31, n=28), and interestingly, their antibody levels were similar to anti-S levels in pre-vaccination exposed individuals. Antibody levels were not different between the sexes.

CONCLUSION:

Anti-S levels differ in individuals given the different vaccines. While further study is required to determine the threshold level for protection against SARSCoV- 2, individuals with low antibody levels may be considered for boosters.
Subject(s)
Search on Google
Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Med J Malaysia Year: 2023 Document Type: Article Affiliation country: Malaysia

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Med J Malaysia Year: 2023 Document Type: Article Affiliation country: Malaysia