CNS Summit 2022

ABSTRACT

The proceedings contain 66 papers. The topics discussed include AI-driven COVID-19 mRNA vaccine degradation prediction;evidence-based clinical trial feasibility and protocol design using artificial intelligence;reducing sample sizes by up to 30% in clinical trials for mood disorders via enhanced primary endpoint reliability using audio-visual multimodal machine learning;the development of an automated EEG-based machine learning pipeline for the detection of Alzheimer's disease a proof of concept for novel clinical trial biomarkers;tools for rapid development of EEG-based pharmacodynamic biomarkers;TWINRCT novel ai-based solution to reduce sample size of control arms;circadian rhythm-related endpoints derived from actigraphy validation of SOMNO-ART;and reliability of real world digital end-points of functional neurophysiology.