Routine and Advanced Cbc Parameters in Covid 19 Patients:Observational Study from a Tertiary Care Centre in India

ABSTRACT

Introduction: The association of hematological abnormalities in severe COVID-19 pneumonia is multifactorial. The hemostatic abnormalities in COVID-19 are related with disease progression, severity and mortality. In this study, we aim to investigate the association of routine hematological parameters along with newer CBC parameters in COVID-19 disease Methods: Retrospective study of 164 RT PCR confirmed COVID-19 patients between May' 20 to Dec'20 D-dimer was estimated by immunometric assay with a reference range of 0-0.35ug/L (Instrument -Nephle plus one) and CBC was run on Sysmex 2000 XN. The patients were divided into mild/moderate, severe and the nonsurvivor outcome groups according to the MoHFW India guidelines.Data are expressed as the mean +/- sd for continuous variable and frequency percentage for categorical variable. Comparisons of three groups were performed using Kruskall Wallis test for continuous variables and Chi square test, Fisher's exact test as appropriate for categorical variables. Result(s) RESULTS Of the 164 admitted cases with an age range of 28-90 years, the majority were males(n-117-71.3%) The Receiver operating characteristic curve analysis showed that Neutrophil lymphocyte ratio at discharge had the highest area under curve (0.713) followed by lymphocyte percentage at discharge (0.712).In advanced CBC parameters lymphocyte Y and lymphocyte Z at discharge had the highest area under the curve (Table Presented) Conclusion(s) As the Pandemic draws to an end and Covid 19 becomes an endemic disease ,the routine and advanced CBC parameters can be used -As a Biomarker for severity of disease at admission -For serial monitoring and prognosis of the patients.