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Challenges Based on Antiplasmodial and Antiviral Activities of 7-Chloro-4-aminoquinoline Derivatives.
Mizuta, Satoshi; Mosaddeque, Farhana; Tun, Mya Myat Ngwe; Teklemichael, Awet Alem; Taniguchi, Mayumi; Hosokawa, Masashi; Yamaguchi, Tomoko; Makau, Juliann; Huy, Nguyen Tien; Mizukami, Shusaku; Nishida, Noriyuki; Morita, Kouichi; Hirayama, Kenji.
  • Mizuta S; Center for Bioinformatics and Molecular Medicine, Nagasaki University, 1-14 Bunkyo, 852-8521, Nagasaki, Japan.
  • Mosaddeque F; Department of Immunogenetics Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Tun MMN; Department of Virology Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Teklemichael AA; Department of Immune Regulation Shionogi Global Infectious Diseases Division, Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Taniguchi M; Department of Immune Regulation Shionogi Global Infectious Diseases Division, Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Hosokawa M; School of Medicine, Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Yamaguchi T; Center for Bioinformatics and Molecular Medicine, Nagasaki University, 1-14 Bunkyo, 852-8521, Nagasaki, Japan.
  • Makau J; Center for Virus Research, Kenya Medical Research Institute, 54840-00200, Nairobi, Kenya.
  • Huy NT; Department of Immunogenetics Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Mizukami S; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, 852-8102>, Nagasaki, Japan.
  • Nishida N; Department of Immune Regulation Shionogi Global Infectious Diseases Division, Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
  • Morita K; Department of Molecular Microbiology and Immunology, Nagasaki University, 1-12-4 Sakamoto, 852-8102, Nagasaki, Japan.
  • Hirayama K; Department of Virology Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, 852-8523, Nagasaki, Japan.
ChemMedChem ; 18(7): e202200586, 2023 04 03.
Article in English | MEDLINE | ID: covidwho-2219680
ABSTRACT
We report the structural functionalization of the terminal amino group of N1 -(7-chloroquinolin-4-yl) butane-1,4-diamine, leading to a series of 7-chloro-4-aminoquinoline derivatives, and their evaluation as potent anti-malarial and anti-viral agents. Some compounds exhibited promising anti-malarial effects against the Plasmodium falciparum 3D7 (chloroquine-sensitive) and Dd2 (chloroquine-resistant) strains. In addition, these compounds were assayed in vitro against influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Compound 5 h, bearing an N-mesityl thiourea group, displayed pronounced anti-infectious effects against malaria, IAV, and SARS-CoV-2. These results provide new insights into drug discovery for the prevention or treatment of malaria and virus co-infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Malaria / Antimalarials Type of study: Experimental Studies Limits: Humans Language: English Journal: ChemMedChem Journal subject: Pharmacology / Chemistry Year: 2023 Document Type: Article Affiliation country: Cmdc.202200586

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Malaria / Antimalarials Type of study: Experimental Studies Limits: Humans Language: English Journal: ChemMedChem Journal subject: Pharmacology / Chemistry Year: 2023 Document Type: Article Affiliation country: Cmdc.202200586