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Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2.
Barreiro, Antonio; Prenafeta, Antoni; Bech-Sabat, Gregori; Roca, Mercè; Perozo Mur, Eva; March, Ricard; González-González, Luis; Madrenas, Laia; Corominas, Júlia; Fernández, Alex; Moros, Alexandra; Cañete, Manuel; Molas, Mercè; Pentinat-Pelegrin, Thais; Panosa, Clara; Moreno, Alberto; Puigvert Molas, Ester; Pol Vilarrassa, Eva; Palmada, Jordi; Garriga, Carme; Prat Cabañas, Teresa; Iglesias-Fernández, Javier; Vergara-Alert, Júlia; Lorca-Oró, Cristina; Roca, Núria; Fernández-Bastit, Leira; Rodon, Jordi; Pérez, Mònica; Segalés, Joaquim; Pradenas, Edwards; Marfil, Silvia; Trinité, Benjamin; Ortiz, Raquel; Clotet, Bonaventura; Blanco, Julià; Díaz Pedroza, Jorge; Ampudia Carrasco, Rosa; Rosales Salgado, Yaiza; Loubat-Casanovas, Jordina; Capdevila Larripa, Sara; Prado, Julia Garcia; Barretina, Jordi; Sisteré-Oró, Marta; Cebollada Rica, Paula; Meyerhans, Andreas; Ferrer, Laura.
  • Barreiro A; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Prenafeta A; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Bech-Sabat G; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Roca M; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Perozo Mur E; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • March R; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • González-González L; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Madrenas L; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Corominas J; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Fernández A; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Moros A; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Cañete M; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Molas M; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Pentinat-Pelegrin T; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Panosa C; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Moreno A; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Puigvert Molas E; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Pol Vilarrassa E; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Palmada J; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Garriga C; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Prat Cabañas T; HIPRA, Avda. La Selva, 135, Amer, 17170 Girona, Spain.
  • Iglesias-Fernández J; Nostrum Biodiscovery, Avenue de Josep Tarradellas, 8-10, 3-2, 08029 Barcelona, Spain.
  • Vergara-Alert J; Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Lorca-Oró C; Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Roca N; Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Fernández-Bastit L; Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Rodon J; Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Pérez M; Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Segalés J; Universitat Autònoma de Barcelona, CReSA (IRTA-UAB), Campus de la UAB, 08193 Cerdanyola del Vallès, Spain.
  • Pradenas E; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Cerdanyola del Vallès, Spain.
  • Marfil S; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Trinité B; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Ortiz R; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Clotet B; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Blanco J; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Díaz Pedroza J; University of Vic-Central University of Catalonia (UVic-UCC), Vic, 08500 Catalonia, Spain.
  • Ampudia Carrasco R; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Rosales Salgado Y; University of Vic-Central University of Catalonia (UVic-UCC), Vic, 08500 Catalonia, Spain.
  • Loubat-Casanovas J; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
  • Capdevila Larripa S; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
  • Prado JG; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
  • Barretina J; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
  • Sisteré-Oró M; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
  • Cebollada Rica P; IrsiCaixa. AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB, 08916 Badalona, Spain.
  • Meyerhans A; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
  • Ferrer L; Comparative Medicine and Bioimage Centre of Catalonia, Germans Trias i Pujol Research Institute (CMCiB-IGTP), 08916 Badalona, Spain.
iScience ; 26(3): 106126, 2023 Mar 17.
Article in English | MEDLINE | ID: covidwho-2220841
ABSTRACT
Current COVID-19 vaccines have been associated with a decline in infection rates, prevention of severe disease, and a decrease in mortality rates. However, SARS-CoV-2 variants are continuously evolving, and development of new accessible COVID-19 vaccines is essential to mitigate the pandemic. Here, we present data on preclinical studies in mice of a receptor-binding domain (RBD)-based recombinant protein vaccine (PHH-1V) consisting of an RBD fusion heterodimer comprising the B.1.351 and B.1.1.7 SARS-CoV-2 variants formulated in SQBA adjuvant, an oil-in-water emulsion. A prime-boost immunisation with PHH-1V in BALB/c and K18-hACE2 mice induced a CD4+ and CD8+ T cell response and RBD-binding antibodies with neutralizing activity against several variants, and also showed a good tolerability profile. Significantly, RBD fusion heterodimer vaccination conferred 100% efficacy, preventing mortality in SARS-CoV-2 infected K18-hACE2 mice, but also reducing Beta, Delta and Omicron infection in lower respiratory airways. These findings demonstrate the feasibility of this recombinant vaccine strategy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines / Variants Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106126

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines / Variants Language: English Journal: IScience Year: 2023 Document Type: Article Affiliation country: J.isci.2023.106126