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Immune-mediated necrotizing myopathy following vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine: A case report and brief review.
Ansari, B; Najafi, M A; Kheradmand, M; Najafi, F; Najafi, M R.
  • Ansari B; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Najafi MA; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Kheradmand M; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Najafi F; Rothman Orthopedics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Najafi MR; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: mreznaj@gmail.com.
Rev Neurol (Paris) ; 179(6): 630-635, 2023 Jun.
Article in English | MEDLINE | ID: covidwho-2221192
ABSTRACT
Immune-Mediated Necrotizing Myopathy (IMNM) after vaccination has been reported previously, however it is rare after COVID-19 vaccination. We report the first case of IMNM two weeks after vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine. There was a probable temporal relationship between the COVID-19 vaccination and the development of IMNM due to lack of known causative factors for IMNM. This may have been due to 1) autoimmunity directly caused by the vaccine, 2) exacerbation of autoimmunity triggered by the vaccine or 3) autoimmune syndrome triggered by the vaccine adjutants. Further studies are needed to assess the underlying mechanisms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / COVID-19 Vaccines / COVID-19 / Muscular Diseases Type of study: Case report / Observational study Topics: Vaccines Limits: Humans Language: English Journal: Rev Neurol (Paris) Year: 2023 Document Type: Article Affiliation country: J.neurol.2022.11.009

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / COVID-19 Vaccines / COVID-19 / Muscular Diseases Type of study: Case report / Observational study Topics: Vaccines Limits: Humans Language: English Journal: Rev Neurol (Paris) Year: 2023 Document Type: Article Affiliation country: J.neurol.2022.11.009