MTOR hypermethylation may associate with the susceptibility and survival of SARS-CoV-2 infections to lung adenocarcinoma patients based on multi-omics data and machine learning
2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022
; : 2397-2402, 2022.
Article
in English
| Scopus | ID: covidwho-2223061
ABSTRACT
Recent studies have shown that lung adenocarcinoma (LUAD) patients have a higher risk and worse prognosis of COVID-19 caused by SARS-CoV-2 compared to normal samples. Whereas, in addition to the receptor for SARS-CoV-2, other genes also deserve attention. In our study, we identified 19 differentially methylated genes (DMGs) that were co-upregulated in LUAD and COVID-19 samples. These 19 DMGs mainly regulated the immune-related and multiple viral infection signaling pathways. Gene Ontology and pathway enrichment analysis were applied with these genes. Then, 6 key DMGs (MTOR, ACE, IGF1, PTPRC, C3, and PTGS2) were identified by constructing and analyzing the protein-protein interaction (PPI) network. Besides, MTOR was significantly associated with 5 prognostic markers (CDO1, NEURL4, SMAP1, NPEPPS, IQCK) identified by survival analysis based on machine learning. In total, MTOR hypermethylation may be related to the susceptibility of LUAD patients to SARS-CoV-2 and the prognosis of LUAD patients suffering from COVID-19. © 2022 IEEE.
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Prognostic study
Language:
English
Journal:
2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022
Year:
2022
Document Type:
Article
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