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Heterogeneity in IgG-CD16 signaling in infectious disease outcomes.
Gonzalez, Joseph C; Chakraborty, Saborni; Thulin, Natalie K; Wang, Taia T.
  • Gonzalez JC; Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
  • Chakraborty S; Program in Immunology, Stanford University School of Medicine, Stanford, California, USA.
  • Thulin NK; Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
  • Wang TT; Department of Immunology, University of Washington, Seattle, Washington, USA.
Immunol Rev ; 309(1): 64-74, 2022 08.
Article in English | MEDLINE | ID: covidwho-2223359
ABSTRACT
In this review, we discuss how IgG antibodies can modulate inflammatory signaling during viral infections with a focus on CD16a-mediated functions. We describe the structural heterogeneity of IgG antibody ligands, including subclass and glycosylation that impact binding by and downstream activity of CD16a, as well as the heterogeneity of CD16a itself, including allele and expression density. While inflammation is a mechanism required for immune homeostasis and resolution of acute infections, we focus here on two infectious diseases that are driven by pathogenic inflammatory responses during infection. Specifically, we review and discuss the evolving body of literature showing that afucosylated IgG immune complex signaling through CD16a contributes to the overwhelming inflammatory response that is central to the pathogenesis of severe forms of dengue disease and coronavirus disease 2019 (COVID-19).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Limits: Humans Language: English Journal: Immunol Rev Year: 2022 Document Type: Article Affiliation country: Imr.13109

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Limits: Humans Language: English Journal: Immunol Rev Year: 2022 Document Type: Article Affiliation country: Imr.13109