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Virology under the Microscope-a Call for Rational Discourse.
Goodrum, Felicia; Lowen, Anice C; Lakdawala, Seema; Alwine, James; Casadevall, Arturo; Imperiale, Michael J; Atwood, Walter; Avgousti, Daphne; Baines, Joel; Banfield, Bruce; Banks, Lawrence; Bhaduri-McIntosh, Sumita; Bhattacharya, Deepta; Blanco-Melo, Daniel; Bloom, David; Boon, Adrianus; Boulant, Steeve; Brandt, Curtis; Broadbent, Andrew; Brooke, Christopher; Cameron, Craig; Campos, Samuel; Caposio, Patrizia; Chan, Gary; Cliffe, Anna; Coffin, John; Collins, Kathleen; Damania, Blossom; Daugherty, Matthew; Debbink, Kari; DeCaprio, James; Dermody, Terence; Dikeakos, Jimmy; DiMaio, Daniel; Dinglasan, Rhoel; Duprex, W Paul; Dutch, Rebecca; Elde, Nels; Emerman, Michael; Enquist, Lynn; Fane, Bentley; Fernandez-Sesma, Ana; Flenniken, Michelle; Frappier, Lori; Frieman, Matthew; Frueh, Klaus; Gack, Michaela; Gaglia, Marta; Gallagher, Tom; Galloway, Denise.
  • Goodrum F; Department of Immunobiology, BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
  • Lowen AC; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Lakdawala S; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Alwine J; Department of Immunobiology, BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
  • Casadevall A; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Imperiale MJ; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Atwood W; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
  • Avgousti D; Brown University, Providence, Rhode Island, USA.
  • Baines J; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Banfield B; Cornell University, Ithaca, New York, USA.
  • Banks L; Queen's University, Kingston, Ontario, Canada.
  • Bhaduri-McIntosh S; International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
  • Bhattacharya D; University of Florida, Gainesville, Florida, USA.
  • Blanco-Melo D; University of Arizona, Tucson, Arizona, USA.
  • Bloom D; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Boon A; University of Florida, Gainesville, Florida, USA.
  • Boulant S; University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Brandt C; University of Florida, Gainesville, Florida, USA.
  • Broadbent A; University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Brooke C; University of Maryland, College Park, Maryland, USA.
  • Cameron C; University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Campos S; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Caposio P; University of Arizona, Tucson, Arizona, USA.
  • Chan G; Oregon Health and Science University, Beaverton, Oregon, USA.
  • Cliffe A; SUNY Upstate Medical University, Syracuse, New York, USA.
  • Coffin J; University of Virginia, Charlottesville, Virginia, USA.
  • Collins K; Tufts University, Boston, Massachusetts, USA.
  • Damania B; University of Michigan, Ann Arbor, Michigan, USA.
  • Daugherty M; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Debbink K; University of California, San Diego, La Jolla, California, USA.
  • DeCaprio J; Johns Hopkins University, Baltimore, Maryland, USA.
  • Dermody T; Harvard Medical School, Boston, Massachusetts, USA.
  • Dikeakos J; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • DiMaio D; Western University, London, Ontario, Canada.
  • Dinglasan R; Yale University, New Haven, Connecticut, USA.
  • Duprex WP; University of Florida, Gainesville, Florida, USA.
  • Dutch R; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Elde N; University of Kentucky, Lexington, Kentucky, USA.
  • Emerman M; University of Utah, Salt Lake City, Utah, USA.
  • Enquist L; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Fane B; Princeton University, Princeton, New Jersey, USA.
  • Fernandez-Sesma A; University of Arizona, Tucson, Arizona, USA.
  • Flenniken M; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Frappier L; Montana State University, Bozeman, Montana, USA.
  • Frieman M; University of Toronto, Toronto, Ontario, Canada.
  • Frueh K; University of Maryland, College Park, Maryland, USA.
  • Gack M; Oregon Health and Science University, Beaverton, Oregon, USA.
  • Gaglia M; Florida Research and Innovation Center, Port Saint Lucie, Florida, USA.
  • Gallagher T; University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Galloway D; Loyola University, Maywood, Illinois, USA.
mBio ; 14(1): e0018823, 2023 02 28.
Article in English | MEDLINE | ID: covidwho-2223573
ABSTRACT
Viruses have brought humanity many challenges respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns - conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we - a broad group of working virologists - seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Viruses / COVID-19 Type of study: Prognostic study / Qualitative research Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: MBio Year: 2023 Document Type: Article Affiliation country: Mbio.00188-23

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Viruses / COVID-19 Type of study: Prognostic study / Qualitative research Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: MBio Year: 2023 Document Type: Article Affiliation country: Mbio.00188-23