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Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms.
Huang, Pei; Zhang, Lin-Yuan; Tan, Yu-Yan; Chen, Sheng-Di.
  • Huang P; Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Zhang LY; Department of Neurology, Shanghai General Hospital, Shanghai, 200080, China.
  • Tan YY; Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. tyy11672@rjh.com.cn.
  • Chen SD; Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. chensd@rjh.com.cn.
Transl Neurodegener ; 12(1): 5, 2023 01 30.
Article in English | MEDLINE | ID: covidwho-2224309
ABSTRACT
The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are still many issues of concern to be clarified. Therefore, we review the current literature on the complex relationship between COVID-19 and neurodegenerative diseases with an emphasis on Parkinson's disease (PD) and Alzheimer's disease (AD). We summarize the impact of COVID-19 infection on symptom severity, disease progression, and mortality rate of PD and AD, and discuss whether COVID-19 infection could trigger PD and AD. In addition, the susceptibility to and the prognosis of COVID-19 in PD patients and AD patients are also included. In order to achieve better management of PD and AD patients, modifications of care strategies, specific drug therapies, and vaccines during the pandemic are also listed. At last, mechanisms underlying the link of COVID-19 with PD and AD are reviewed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Neurodegenerative Diseases / Alzheimer Disease / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transl Neurodegener Year: 2023 Document Type: Article Affiliation country: S40035-023-00337-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Neurodegenerative Diseases / Alzheimer Disease / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transl Neurodegener Year: 2023 Document Type: Article Affiliation country: S40035-023-00337-1