COVID-19 infection in kidney transplant recipients during the first versus the second wave-Retrospective Observational study from a single center
Indian Journal of Transplantation
; 16(4):361-365, 2022.
Article
in English
| Web of Science | ID: covidwho-2225961
ABSTRACT
Background:
Kidney transplant recipients (KTRs) are deemed to be at a high risk of severe coronavirus disease (COVID-19). Herein, we describe the clinical, laboratory profiles, management, and outcomes of 26 KTRs who developed COVID-19 during the first and second waves of the pandemic from a tertiary care center in northern India.Methods:
This retrospective observational study included KTRs detected with COVID-19 infection during the first wave (March-November 2020) and the second wave (March-July 2021). Their clinical and laboratory investigations, management aspects, and outcomes were compared, using data retrieved from clinical and telenephrology records, and the hospital information system.Results:
Of the 23 KTRs, 20 were male (86%), 20 patients had fever (86%), and cough and breathlessness were seen in 19 (82%) and 12 (52%), respectively. Acute graft dysfunction was seen in 6 (26%) patients, and the need for renal replacement was seen in 4 (17%) patients. Supplemental oxygen by reservoir mask was utilized in 10 (43%) patients, high-flow nasal cannula in 3 (13%), noninvasive mechanical ventilation in 4 (17%), and invasive mechanical ventilation in 6 (26%) patients. All the KTRs with moderate and severe COVID illness and 6/7 nonsurvivors were infected during the second wave. Overall mortality in this group of patients was very high at 27%, and the mortality in the group on mechanical ventilation was 100%.Conclusions:
The second wave of the COVID-19 pandemic was associated with greater severity of illness and high mortality in KTRs.
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian Journal of Transplantation
Year:
2022
Document Type:
Article
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