Your browser doesn't support javascript.
Favipiravir therapy for Covid-19 infection and tacrolimus toxicity in a kidney transplant patient on chronic eculizumab therapy.
Dincer, Mevlut Tamer; Trabulus, Sinan; Seyahi, Nurhan.
  • Dincer MT; Department of Nephrology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Fatih, Istanbul 34360, Turkey.
  • Trabulus S; Department of Nephrology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Fatih, Istanbul 34360, Turkey.
  • Seyahi N; Department of Nephrology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Fatih, Istanbul 34360, Turkey.
Natl Med J India ; 35(4): 232-234, 2022.
Article in English | MEDLINE | ID: covidwho-2226592
ABSTRACT
Although the latest data show that complement activation has an essential role in the pathogenesis and severity of Covid-19, the data on the prognosis of patients using complement inhibitors during Covid-19 infection are scarce. There is no specific treatment for Covid-19 yet. The introduction of novel agents such as favipiravir may affect metabolism of immunosuppressive drugs. We report the clinical course of Covid-19 in a kidney transplant patient with atypical haemolytic uraemic syndrome on chronic eculizumab therapy. The patient had mild Covid-19 but had severe tacrolimus toxicity, which may be associated with favipiravir and eculizumab. The mild course of Covid-19 in our patient is encouraging for eculizumab use; on the other hand, unusually high levels of tacrolimus that we observed underlines the importance of frequent drug level monitoring in transplanted patients who are receiving new drugs.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Natl Med J India Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: NMJI_378_21

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Natl Med J India Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: NMJI_378_21