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Outcomes of COVID-19 patients with acute kidney injury and longitudinal analysis of laboratory markers during the hospital stay: A multi-center retrospective cohort experience from Pakistan.
Ahsan, Muhammad Nadeem; Asghar, Muhammad Sohaib; Iqbal, Sadia; Alvi, Haris; Akram, Mohammed; Fayyaz, Basmah; Irshad, Syeda Ghazala; Ullah, Irfan; Alvi, Sarosh; Yousaf, Zohaib.
  • Ahsan MN; Department of Nephrology, Dow University of Health Sciences-Ojha Campus, Karachi, Pakistan.
  • Asghar MS; Department of Internal Medicine, Dow University of Health Sciences-Ojha Campus, Karachi, Pakistan.
  • Iqbal S; Department of Internal Medicine, Dow University of Health Sciences-Ojha Campus, Karachi, Pakistan.
  • Alvi H; Department of Internal Medicine, Dow University of Health Sciences-Ojha Campus, Karachi, Pakistan.
  • Akram M; Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan.
  • Fayyaz B; Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan.
  • Irshad SG; Department of Nephrology, Dow University of Health Sciences-Ojha Campus, Karachi, Pakistan.
  • Ullah I; Department of Internal Medicine, Kabir Medical College Gandhara University, Peshawar, Pakistan.
  • Alvi S; Teaching Faculty, University of Khartoum, Khartoum, Sudan.
  • Yousaf Z; Department of Internal Medicine, Reading Hospital - Tower Health, Reading, PA.
Medicine (Baltimore) ; 102(6): e32919, 2023 Feb 10.
Article in English | MEDLINE | ID: covidwho-2227150
ABSTRACT
The frequency of acute kidney injury (AKI) in COVID-19 patients can be varied and related to worse outcomes in the disease population. AKI is common among hospitalized patients with COVID-19, particularly the ones needing critical care. This study was conducted in order to determine the outcomes of hospitalized patients with prolonged hospital stays who suffered from COVID-19 associated AKI. It was conducted as a multi-centered, retrospective, cohort study, and including all patients who were diagnosed on COVID-19 PCR. End-stage renal disease patients on hemodialysis were excluded. The cohort included 1069 patients, with 68% males, mean age of 56.21 years, and majority within 50 to 75 years age group (60%). Mean disease onset was 14.43 ± 7.44 days and hospital stay was 7.01 ± 5.78 days. About 62% of patients stayed in intensive care and 18% of them were on invasive ventilation. The mortality rate was 27%. Frequency of AKI was 42%, around 14% of them were resolving during hospital stay and other 28% worsened. The mortality rate was significantly higher with AKI (OR 4.7, P < .001). Alongside AKI, concomitant liver dysfunction was also significantly contributing to mortality (OR 2.5), apart from ICU stay (OR 2.9), invasive ventilation (OR 9.2), and renal replacement therapy (OR 2.4). Certain laboratory markers were associated with AKI throughout in-hospital stay.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2023 Document Type: Article Affiliation country: Md.0000000000032919

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2023 Document Type: Article Affiliation country: Md.0000000000032919