Acute Limb Ischemia among COVID-19 Patients in Hospital Kuala Lumpur

ABSTRACT

BACKGROUND: Acute arterial thromboembolism among the novel coronavirus 2019 (COVID-19) patients is worrying as it can result in significant thrombotic events. AIM: The research aimed to determine the clinical results of COVID-19-infected patients who had acute limb ischemia (ALI) during the COVID-19 epidemic. METHOD(S) ALI patients who had a positive COVID-19 were included in the observational cohort study, which was conducted at a single center. The primary outcomes were 30 days mortality, limb salvage, and successful revascularization. RESULT(S) From May to October 2021, data from 21 ALI subjects who had positive COVID-19 were analyzed. Of the 21 included subjects, 10 were male (48%). Their mean age was 65 +/- 5 years. In 9 subjects (42%), revascularization was done. Four (19%) of the 21 persons died while they were hospitalized. Twelve patients underwent major amputation, and among them, one patient died after a month of hospitalization for COVID-19-related pneumonia. Among the 12 patients that underwent amputation, 10 of them presented with ALI during the 1st week of COVID-19 illness. Only one patient developed acute limb ischemia despite being on heparin thromboprophylaxis. CONCLUSION(S) Despite attempts at revascularization, ALI associated with COVID-19 has high mortality and high rates of limb loss. In our experience, major amputation is required in up to a third of patients. This poor result appears to confirm that these infected individuals have a marked hypercoagulable condition. However, adhering to the treatment protocol of heparin thromboprophylaxis confers a benefit in this patient group. Copyright © 2022 Karthigesu Aimanan, Nurul Nadiah Nazurah Mohd Ali, Mohd Nurhisham Azmi Abdul Rahman, Putra Mas Pian, Kumaraguru V. K. Pillay, Firdaus Hayati, Hanif Hussein.