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The relationship between anti-spike SARS-CoV-2 antibody levels and risk of breakthrough COVID-19 among fully vaccinated adults.
Asamoah-Boaheng, Michael; Goldfarb, David M; Karim, Mohammad Ehsanul; O'Brien, Sheila F; Wall, Nechelle; Drews, Steven J; Barakauskas, Vilte; Jassem, Agatha N; Grunau, Brian.
  • Asamoah-Boaheng M; Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Goldfarb DM; Faculty of Medicine, Clinical Epidemiology, Memorial University of Newfoundland, St John's, Newfoundland & Labrador, Canada.
  • Karim ME; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • O'Brien SF; Centre for Health Evaluation & Outcome Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
  • Wall N; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Drews SJ; Canadian Blood Services, Vancouver, British Columbia, Canada.
  • Barakauskas V; School of Epidemiology & Public Health, University of Ottawa, Ottawa, Ontario, Canada.
  • Jassem AN; British Columbia Emergency Health Services, Vancouver, British Columbia, Canada.
  • Grunau B; Canadian Blood Services, Vancouver, British Columbia, Canada.
J Infect Dis ; 2022 Oct 05.
Article in English | MEDLINE | ID: covidwho-2227689
ABSTRACT
The relationship between antibodies to wild-type SARS-CoV-2 antigens and the risk of breakthrough infections is unclear, especially during time periods of Omicron. We investigated the association of anti-spike and anti-receptor binding domain antibody levels and the risk of subsequent breakthrough COVID-19. We included adult paramedics from an observational cohort study who received ≥ 2 mRNA vaccines but did not have COVID-19 before the blood collection. Higher post-vaccine antibody levels to wild-type SARS-CoV-2 antigens were associated with a reduced risk of COVID-19. Further research into clinical utility of antibody levels, to inform a threshold for protection and timing of boosters, should be prioritized.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Infdis