Your browser doesn't support javascript.
Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS.
Babu, Vedesh Kumar; Rojas, Pedro; Perez Del Nogal, Genesis; Garcia-Fernandez, Alejandra.
  • Babu VK; Internal Medicine Residency, Texas Tech University Health Sciences Center School of Medicine, Odessa, Texas, USA vebabu@ttuhsc.edu.
  • Rojas P; Internal Medicine Residency, Texas Tech University Health Sciences Center School of Medicine, Odessa, Texas, USA.
  • Perez Del Nogal G; Internal Medicine Residency, Texas Tech University Health Sciences Center School of Medicine, Odessa, Texas, USA.
  • Garcia-Fernandez A; Internal Medicine Residency, Texas Tech University Health Sciences Center School of Medicine, Odessa, Texas, USA.
BMJ Case Rep ; 16(2)2023 Feb 07.
Article in English | MEDLINE | ID: covidwho-2227800
ABSTRACT
An elderly man presenting with shortness of breath and hypoxaemia was admitted with acute hypoxic respiratory failure secondary to COVID-19 pneumonia. Due to worsening hypoxaemia, he was transferred to the intensive care unit and required mechanical ventilation. Propofol was infused at 1.5-4 mg/kg/hour. Within 48 hours of initiation, we noticed worsening metabolic acidosis, acute kidney injury, hyperkalaemia, hyperphosphataemia, hypertriglyceridaemia, elevated creatine kinase and elevated myoglobin levels. Suspecting propofol-related infusion syndrome (PRIS), we discontinued his propofol infusion immediately and initiated supportive measures. In 48 hours, there was a significant improvement in metabolic acidosis, hypertriglyceridaemia, rhabdomyolysis and renal function. The propofol infusion rate and cumulative propofol dosage (under 140 mg/kg) were well below levels associated with PRIS. COVID-19's pathogenesis, still under investigation, may have contributed to this presentation. It is imperative for clinicians to maintain a high degree of suspicion once propofol is initiated, regardless of the cumulative dose or rate of infusion.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Acidosis / Hypertriglyceridemia / Propofol / Propofol Infusion Syndrome / COVID-19 / Hyperlipidemias Type of study: Case report Limits: Aged / Humans / Male Language: English Year: 2023 Document Type: Article Affiliation country: Bcr-2022-249456

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Acidosis / Hypertriglyceridemia / Propofol / Propofol Infusion Syndrome / COVID-19 / Hyperlipidemias Type of study: Case report Limits: Aged / Humans / Male Language: English Year: 2023 Document Type: Article Affiliation country: Bcr-2022-249456