Effect Of Different MAC Values On Bispectral Index In Isoflurane Anaesthesia
Journal of Pharmaceutical Negative Results
; 13:7299-7305, 2022.
Article
in English
| EMBASE | ID: covidwho-2227834
ABSTRACT
Introduction:
The bispectral index monitors the unawareness component of balanced anaesthesia and gives us the depth of Anesthesia.It reflects the response of the brain to a variety of hypnotic and inhaled anaesthesia agents. The aim of this study was to see the effect of different MAC values of isoflurane on the bispectral index and hemodynamic variations at different MAC values. Material(s) and Method(s) This prospective study was conducted on 20 patients at tertiary care center for 6 months. After induction of Anesthesia, following parameters were recorded noninvasive blood pressure measurement, heart rate, oxygen saturation, ETCo2 and BIS values. The BIS was continuously monitored and when the MAC values of isoflurane were 0.5, 0.7, 1, 1.2 and 1.5 corresponding BIS values and all the other haemodynamic parameters were noted. Result(s) In 11 patients out of 20 patients satisfactory BIS of 40-60 was achieved at MAC 0.5. In 16 out of 20 patients satisfactory BIS 40-60 was achieved at 0.7 MAC. In all the 20 patients satisfactory BIS was achieved at 1 MAC.In 2 out of 20 patients we couldn't proceed beyond 1.0 MAC because of the fall in MAP to <65mm of Hg. In 4 out of 20 patients we couldn't proceed beyond 1.2MAC because of the fall in MAP to <65mm of Hg. Conclusion(s) Isoflurane produced satisfactory BIS of 40-60 in 16 patients at 0.7 MAC and in all the 20 patients at 1 MAC.Use of BIS in our study helped in better titration of Isoflurane according to patient's individual needs thereby we avoided light plane of anaesthesia or deep hypnosis and the adverse effects associated with it. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
Bispectral Index; Isoflurane; Minimum alveolar concentration; adult; anesthesia; anesthesia induction; article; artificial ventilation; blood pressure measurement; body weight; clinical article; clinical effectiveness; comparative study; controlled study; endotracheal intubation; female; heart rate; hemodynamic parameters; hemodynamics; human; hypnosis; lung alveolus; male; minimum lung alveolus concentration; oxygen saturation; patient satisfaction; prospective study; tertiary care center; titrimetry; vital sign; fentanyl/iv [Intravenous Drug Administration]; isoflurane/ih [Inhalational Drug Administration]; propofol/iv [Intravenous Drug Administration]; vecuronium/iv [Intravenous Drug Administration]; bispectral index monitor; endotracheal tube; covidien
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Journal of Pharmaceutical Negative Results
Year:
2022
Document Type:
Article
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